Table 1. One-Pot Three-Component CuAAC Reaction by Different Catalystsa.
| entry | catalyst (mg) | time (min) | yield (%)b |
|---|---|---|---|
| 1 | CsCu2I3@PCN-222(Fe)-15 min-r.t. (10) | 85 | 98 |
| 2 | CsCu2I3@PCN-222(Fe)-15 min-60 °C (10) | 80 | 98 |
| 3 | CsCu2I3@PCN-222(Fe)-3.5 h-60 °C (10) | 30 | 98 |
| 4 | CsCu2I3@PCN-222(Fe)-3.5 h-r.t. (10) | ∼30 | 98 |
| 5 | PCN-222(Fe) (7) | 60 | |
| 6 | CsCu2I3 (7) | 30 | 80 |
| 7 | PCN-222(Fe) (7) + CsCu2I3 (7) | 30 | 85 |
a
Reaction conditions: benzyl chloride (0.5 mmol), NaN3 (1 mmol), phenylacetylene (1 mmol), water (2 mL), and catalyst.
b
Purified yield.