. 2022 Sep 6;207(4):438–451. doi: 10.1164/rccm.202206-1230OC

Table 1.

Demographics (Mean ± SD) of Participants with mRNA Expression Measured in Bronchial Epithelial Cells

SARP Cross-sectional Cohort Microarray mRNA (n = 155)	Nonsmoking Control Subjects (n = 27)	Nonsmoking Asthma^* (n = 128)	Nonsevere Asthma^† (n = 78)	Severe Asthma^† (n = 50)	P Value^‡ (Asthma vs. Control Subjects)	P Value^‡ (Severe vs. Nonsevere)
Age at enrollment, yr	33 ± 13	37 ± 13	33 ± 12	44 ± 11	0.19	<0.0001
Sex, n (%) female	15 (56)	86 (67)	51 (65)	35 (70)	0.27	0.7
Race (% White/African American/other^§)	70/19/11	60/31/9	56/32/11	65/29/6	0.43	0.55
Body mass index, kg/m²	26 ± 5.2	30 ± 6.9	29 ± 6.7	32 ± 7.0	0.0016	0.029
Baseline Pre-BD FEV₁% predicted^ǁ	94 ± 9.1	72 ± 22.1	82 ± 17	56 ± 20	<0.0001	<0.0001
Baseline Pre-BD FEV₁/FVC^ǁ	0.81 ± 0.04	0.70 ± 0.12	0.75 ± 0.09	0.61 ± 0.12	<0.0001	<0.0001

SARP Longitudinal Cohort RNAseq (n = 156)	Nonsmoking Control Subjects (n = 42)	Nonsmoking Asthma^* (n = 114)	Nonsevere Asthma^† (n = 52)	Severe Asthma^† (n = 62)	P value^‡ (Asthma vs. Control Subjects)	P value^‡ (Severe vs. Nonsevere)
Age at enrollment, yr	41 ± 13	41 ± 13	37 ± 12	44 ± 13	0.92	0.0032
Sex, n (%) female	25 (60)	74 (65)	34 (65)	40 (65)	0.58	1
Race (% White/African American/other^§)	69/17/14	63/25/12	67/21/12	60/27/13	0.57	0.69
Body mass index, kg/m²	28 ± 5.5	31 ± 8.7	30 ± 9.1	32 ± 8.3	0.033	0.025
Baseline Pre-BD FEV₁% predicted^ǁ	99 ± 12	76 ± 19	85 ± 15	69 ± 20	<0.0001	<0.0001
Baseline Pre-BD FEV₁/FVC^ǁ	0.81 ± 0.04	0.70 ± 0.08	0.73 ± 0.09	0.68 ± 0.10	<0.0001	0.015

Definition of abbreviations: Pre-BD = prebronchodilator; SARP = Severe Asthma Research Program.

For the longitudinal cohort, nonsmokers were never-smokers or previous smokers with less than 5 to 10 pack-years of tobacco use, depending on age. For the cross-sectional cohort, nonsmokers were never-smokers or previous smokers with less than 5 pack-years of tobacco use.

^{^†}

Asthma severity (nonsevere or severe asthma) was on the basis of American Thoracic Society–European Respiratory Society criteria (29).

^{^‡}

P value was generated using the Kruskal-Wallis test.

^{^§}

Other races include Hispanic, Asian, American Indian, and mixed.

^{^ǁ}

Pre-BD pulmonary function was presented.