Table 3.

Association of CC16 mRNA Expression Levels in Bronchial Epithelial Cells with Pulmonary Function in Asthmatics

SARP Cross-sectional Cohort Microarray mRNA (Asthmatics, n = 128)	Baseline Prebronchodilator FEV1% Predicted (n = 128) β (P Value)*	Baseline Prebronchodilator FEV1/FVC (n = 127) β (P Value)*
	CC16 mRNA expression levels (log2)	4.99 (0.0021)	0.031 (0.0005)

SARP Longitudinal Cohort RNAseq (Asthmatics, n = 114)	Baseline Prebronchodilator FEV1% Predicted (n = 114) β (P value)*	Baseline Prebronchodilator FEV1/FVC (n = 114) β (P value)*
	CC16 mRNA expression levels (ln)	5.69 (0.0008)	0.032 (0.0003)

Definition of abbreviations: ln = natural logarithm; log2 = logarithm base 2; RNAseq = RNA sequencing; SARP = Severe Asthma Research Program.

^*Regression slope (β) and P value were generated using a linear regression model adjusted for age, sex, body mass index, race, and batch effect. CC16 mRNA expression levels were log2- and ln-transformed in the SARP cross-sectional cohort and longitudinal cohort, respectively.