Table 6.

Genes with Expression Levels Significantly Correlated with CC16 mRNA Expression Levels in Bronchial Epithelial Cells

Gene	SARP Cross-sectional Cohort (n = 155)		SARP Longitudinal Cohort (n = 156)		Meta-analysis of SARP Cohorts (n = 311)
	rho*	P Value*	rho*	P Value*	rho†	P Value†
IL12A	0.34	2.02 × 10−5	0.39	4.39 × 10−7	0.37	5.55 × 10−14
MUC5B	0.47	4.26 × 10−10	0.47	6.05 × 10−10	0.48	1.53 × 10−27
TLR5	0.49	1.35 × 10−10	0.54	<2.20 × 10−16	0.52	3.04 × 10−35
C3	0.51	1.93 × 10−11	0.48	2.31 × 10−10	0.50	3.48 × 10−31
CXCL6	0.44	9.26 × 10−9	0.47	1.01 × 10−9	0.46	2.10 × 10−24
IL18R1	−0.37	1.66 × 10−6	−0.32	4.38 × 10−5	−0.35	1.37 × 10−12
MUC5AC	−0.30	1.87 × 10−4	−0.47	5.67 × 10−10	−0.39	6.69 × 10−16
PLA2G4A	−0.44	1.31 × 10−8	−0.37	2.54 × 10−6	−0.40	1.07 × 10−17
POSTN	−0.41	1.09 × 10−7	−0.32	4.00 × 10−5	−0.37	3.28 × 10−14
SERPINB2	−0.26	1.09 × 10−3	−0.41	1.92 × 10−7	−0.33	1.91 × 10−11
CLCA1	−0.42	6.74 × 10−8	−0.52	<2.20 × 10−16	−0.47	1.09 × 10−26
IL1RL1	−0.39	6.36 × 10−7	−0.44	1.07 × 10−8	−0.42	4.55 × 10−19
NOS2	−0.42	7.61 × 10−8	−0.39	7.96 × 10−7	−0.40	1.82 × 10−17

Definition of abbreviation: SARP = Severe Asthma Research Program.

A subset of genes was presented in this table, whereas the full table was presented in Table E1.

^*Correlation coefficient (rho) and P value were generated using a Spearman correlation model in which genes were inverse normalized with age, sex, body mass index, race, batch effect, and asthma status.

^† Correlation coefficient (rho) and P value were generated on the basis of Olkin-Pratt fixed-effect meta-analytical model using metacor R package (46).