Fig. 1. Chemical space and contemporary library synthesis strategies. (A) The vastness of chemical space makes systematic exploitation very demanding. (B) Combinatorial chemistry and DNA-encoded library (DEL). (C) Fragment-based drug design (FBDD), structure-based drug design (SBDD), diversity-oriented synthesis (DOS) and virtual screening (VS). (D) Herein pursued approach involving HT miniaturized multiple chemistries at once using rapid acoustic droplet ejection technology.
