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. 2023 Feb 6;14:1114006. doi: 10.3389/fimmu.2023.1114006

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Copyright © 2023 Wang, Zhang, Cheng, Ren, Xu, Li, Wang and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of the DEPs continuously up- or downregulated with age. (A) Six clusters of the 513 DEPs in the three groups. A refers to the children, B refers to the middle-aged individuals, and C refers to the older individuals. (B) Representative biological process analysis of cluster 3 (left) and cluster 4 (right). (C, D) Activation or inhibition of several canonical signaling pathways in cluster 3 and cluster 4. (E, F) The core molecular of cluster 3 and cluster 4.