Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Dissociation constants for FcγR binding to IgG.
| FcγRI | Affinity (KD, nM) | |||
|---|---|---|---|---|
| IgG1 | IgG2 | IgG3 | IgG4 | |
| WT | 13.0±6 | 41.0±29.3 | 28.6±19.9 | 65.7±53.0 |
| H174R | 9.0±4 | 32.8±12.5 | 24.2±18.5 | 108.8±54.7 |
| H174E | 250.6±115 | |||
| K173A/H174A/R175A (AAA) | 180.0±42 | |||
| K173E/H174E/R175E (EEE) | 418 ± 198 | |||
| V132L/Y176V | 25.8±28.2 | |||
| FcγRIII | IgG1(KD, µM) | |||
| WT | 3.4±9 | |||
| L118V | 14.7±1.9 | |||
| V163Y | 4.4±2.1 | |||
| L118V/V163Y | 4.8±0.4 | |||
| pH-dependent binding to anti-BSA (KD, nM) | ||||
| 7.5 | 4.6 | 4.0 | ||
| FcγRI | 13.5±3.8 | 193±176 | ND | |
| BSA | 7.8±1.8 | 10.1±14.5 | 1.8±1.1 | |
