Table 1.
Hypergeometric distribution analysis of transcriptional targets of ASD-related TFs and BPA-responsive genes in the hippocampus of male and female offspring
| Male (2078 DEGs) | Female (3055 DEGs) | Both sexes (4525 DEGs) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| TFs | TRANSFAC Curated p value (#overlapping genes/#targets) |
TRANSFAC Predicted p value (#overlapping genes/#targets) |
CHEA p value (#overlapping genes/#targets) |
TRANSFAC Curated p value (#overlapping genes/#targets) |
TRANSFAC Predicted p value (#overlapping genes/#targets) |
CHEA p value (#overlapping genes/#targets) |
TRANSFAC Curated p value (#overlapping genes/#targets) |
TRANSFAC Predicted p value (#overlapping genes/#targets) |
CHEA p value (#overlapping genes/#targets) |
| AR | 0.038 (96/755) | NA | 0.999 (595/6279) | 0.574 (135/755) | NA | 0.999 (1011/6279) | 0.994 (179/755) | NA | 0.999 (1536/6279) |
| ESR1 | 0.027 (63/465) | NA | 0.692 (234/2253) | 0.426 (86/465) | NA | 0.235 (420/2253) | 0.854 (119/465) | NA | 0.730 (611/2253) |
| EGR2 | 0.560 (20/190) | NA | NA | 0.044 (44/190) | NA | NA | 0.685 (50/190) | NA | NA |
| KDM5B | NA | NA | 2.06E−07 (463/3555) | NA | NA | 2.90E−05 (725/3555) | NA | NA | 0.985 (932/3555) |
| SOX5 | 6.16E−04 (45/258) | NA | NA | 0.029 (59/258) | NA | NA | 0.892 (63/258) | NA | NA |
| SMAD4 | 0.435 (26/233) | 0.033 (338/2904) | 0.125 (493/4430) | 0.337 (45/233) | 0.072 (553/2,904) | 0.890 (775/4430) | 0.997 (47/233) | 0.999 (703/2904) | 0.999 (1140/4430) |
| TCF7L2 | NA | NA | 0.826 (54/565) | NA | NA | 0.311 (107/565) | NA | NA | 0.040 (175/565) |
| YY1 | 0.020 (97/744) | 0.961 (151/1,602) | 0.660 (260/2488) | 0.087 (149/744) | 0.970 (263/1602) | 0.997 (402/2488) | 0.986 (180/744) | 0.999 (391/1602) | 0.999 (598/2488) |
Values in bold represent statistically significant results
Transcriptional targets of each TF were obtained from the TRANSFAC Curated, the TRANSFAC Predicted, and the CHEA databases through the Harmonizome database. The lists of DEGs in the hippocampus of male and female pups prenatally exposed to BPA were obtained from our previously published transcriptome profiling study [13]. A p value < 0.05 was considered significant
NA not applicable