Table 2.

Neurological diseases and functions associated with AR target genes that were differentially expressed in the hippocampus of male offspring prenatally exposed to BPA

Diseases or functions	p values	Genes	Number of genes
Neurological disorders
Autism spectrum disorder or intellectual disability	1.04E−07	Adnp, Chd2, Cic, Dst, Gria3, Kirrel3, Kmt2b, Kmt2c, Kmt2d, Mef2c, Nipbl, Nsd1, Slc25a12, Snap25, Sptan1, Syncrip, Tnrc6c, Wdfy3, Zic1, Zmynd8	20
Microcephaly	1.16E−05	Adnp, Hspg2, Kmt2c, Kmt2d, Nsd1, Sptan1, Tp53bp1, Trps1, Wdfy3	9
Growth failure or short stature	3.08E−05	Ckb, Eif2ak3, Hspg2, Itpkb, Jup, Kdm2a, Kmt2b, Kmt2c, Lrp1, Mef2c, Tial1, Tp53bp1, Trps1, Txnip, Zic1	15
Abnormal morphology of embryonic tissue	9.06E−05	Adnp, Epn1, H2az1, Itgb8, Jup, Kdm2a, Kmt2b, Mef2c, Nsd1, Pam, Pou3f3, Zfpm1	12
Pervasive developmental disorder	1.42E−04	Adnp, Dst, Kirrel3, Kmt2b, Mef2c, Slc25a12, Syncrip, Wdfy3	8
Global developmental delay	1.75E−04	Adnp, Elavl2, Gria3, Kmt2b, Nipbl, Pou3f3, Snap25	7
Nervous system development and functions
Proliferation of neuronal cells	1.87E−05	Adnp, Dagla, Epha2, Epn1, Erbb4, Kdm2a, Map1b, Otp, Pkp4, Sema4c, Snap25, Spock2, Zfyve26	13
Developmental process of synapse	1.97E−04	Adnp, Caprin1, Epha7, Erbb4, Kirrel3, Mef2c, Slitrk1	7
Excitatory postsynaptic potential	8.25E−04	Caprin1, Gria3, Mef2c, Rims2, Snap25	5
Docking of synaptic vesicles	1.36E−03	Rims2, Snap25	2
Neuritogenesis	1.55E−03	Caprin1, Ckb, Csmd3, Epha7, Erbb4, Kirrel3, Lrp1, Map1b, Neo1, Pkp4, Slitrk1	11
Behaviors
Abnormal posture	5.75E−04	Caprin1, Eif2ak3, Trps1, Zfyve26	4
Cognition	3.13E−03	Adnp, Cic, Ckb, Erbb4, Kmt2b, Kmt2d, Nipbl, Snap25, Zfpm1	9

Biological functions and diseases associated with AR transcriptional targets that were differentially expressed in the hippocampus of male offspring prenatally exposed to BPA were predicted using IPA software. Statistical significance was determined using Fisher’s exact test. A p value < 0.05 was considered significant