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. 2023 Feb 20;15:11. doi: 10.1186/s13073-023-01160-z

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — TREM2 isoforms expression increases in Alzheimer’s disease. A Expression analysis of TREM2 isoforms (TREM2²³⁰, TREM2²²², and TREM2²¹⁹) in different brain regions in control subjects (Control) and patients with late-onset Alzheimer’s disease (AD) using the AMP-AD dataset. B Design of qPCR primers to specifically detect TREM2 isoforms. C qPCR expression analysis of TREM2 isoforms in middle frontal gyrus tissue of control subjects (C) and patients with Alzheimer’s disease (AD). Statistical analysis was performed by the Student t-test for TREM2²³⁰ and Mann-Whitney test for TREM2²²² and TREM2²¹⁹. D qPCR expression analysis of TREM2 isoforms in brain cortical tissue of 7-month-old control and 5xFAD mice expressing human TREM2 gene (B6^hT2and 5xFAD^hT2). Animals from both sexes were analyzed together (3 males and 1 female B6^hT2; 3 males and 3 females 5xFAD^hT2). Statistical analysis was performed by the Student t-test. Data are expressed as mean values ± SEM (**P < 0.01; ***P < 0.001)