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. 2023 Feb 20;15:11. doi: 10.1186/s13073-023-01160-z

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Soluble TREM2 species inhibit long-term potentiation (LTP). Electrophysiology analysis of LTP in C57BL/6J mice brain slices incubated with soluble TREM2 species at 15 ng/ml. A–C Incubations with sTREM2^H157, sTREM2²²², and sTREM2²¹⁹, respectively. For each isoform, a time course with the average fESP slopes (% baseline) is shown with an arrow that indicates the time of stimulation (left panel) accompanied by a representative fEPSP trace (middle panel) and the quantification of the last 10 min of fESP slope measurements (% baseline) (right panel). A Fifteen recordings from 10 animals for control and 13 recordings from 6 animals for sTREM2^H157. B, C Seven recordings from 6 animals for both control and proteins. Statistical analysis was performed by the Mann-Whitney tests for sTREM2^H157 and sTREM2²²² and the Student t-test for sTREM2²¹⁹. Data are expressed as mean values ± SEM (**P < 0.01; ***P < 0.001)