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. 2023 Feb 20;42:49. doi: 10.1186/s13046-023-02616-1

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Both in vivo assay and clinical analysis data confirmed that AQP1 induced breast cancer progression by interacting with ANXA2 and Rab1b. a-e Survival times between animal groups were compared (log-rank test). The Flag-AQP1/MDA-MB-231 (n = 20) mice group had a shorter survival time compared with Flag-vector/MDA-MB-231 (n = 14) mice group (a); Flag-AQP1/shANXA2 #1/MDA-MB-231 (n = 17) mice group (b) and Flag-AQP1/shRab1b #1/MDA-MB-231 (n = 20) mice group (c) also had a longer survival time when compared with Flag-AQP1/MDA-MB-231 (n = 20) mice group; The survival time was not changed between shANXA2 #1/MDA-MB-231 (n = 19) and Flag-AQP1/shANXA2 #1/MDA-MB-231 (n = 17) mice group (d); Comparison of survival curve between shRab1b #1/MDA-MB-231 (n = 20) and Flag-AQP1/shRab1b #1/MDA-MB-231 (n = 20) mice group (e). f, g Kaplan–Meier analysis of survival of 194 IDC patients with AQP1 high cytoplasmic expression or AQP1 low cytoplasmic expression (log-rank test). h Overview of the AQP1/ANXA2/Rab1b signaling pathway in breast cancer local invasion