Table 3.
Genome wide association studies in migraine from 2010 to 2022
| Article | Population | Number of SNPs tested | Number of loci identified, P < 5 × 10−8 |
Number of new loci, P < 5 × 10− 8 |
Genes or nearest genes | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Origin | Migraine (n) | MO (n) | MwA + MO (n) | MwA only (n) | Controls (n) | |||||
| Antilla et al., 2010 [116] | Europeans | 2748 | 17 | 2142 | 589 | 10,747 | 429,912 |
1 12a |
1 12a |
Intergenic between MTDH/AEG-1 and PGCP MTDH/AEG-1 PGCP, SMYD3, INSIG2, TRPM8, MYLK4, ZNF311, NAV2, COG3, SGCZ, AQP9.a |
| Ligthart et al., 2011 [123] | Europeans | 2446 | NA | NA | NA | 8534 | 2,394,913 |
0 10a |
0 10a |
- NGFR, AGBL1, MACC1, LIPG, AGA, KIF20B, BMP2, IGLL1, TSPAN2, KDM4C.a |
| Chasman et al., 2012 [117] | American women with European ancestry | 5122 | 1826 | 1177 | 18,108 | 2,608,509 |
0 7b |
0 7b |
- PRDM16, TRPM8, SEPT7, C8orf79, LRP1.b |
|
| Freilinger et al., 2012 [124] | Europeans | 2326 | 2326 | 0 | 0 | 4580 | Approximately 1.4 M |
1 12a |
1 12a |
MEF2D MEF2D, HFM1, RABGAP1L, MARCH4, TGFBR2, RGS12, PHACTR1, FHL5, ADAM28, ASTN2, INA, MMP17.a |
| Anttila et al., 2013 [118] | European descent | 23,285 | 7107 | 5118 | 95,425 | Approximately 2.3 M | 12 | 5 | AJAP1, TSPAN2, FHL5, c7orf10, MMP16, PRDM16, MEF2D, TRPM8, TGFBR2, PHACTR1, ASTN2, LRP1. | |
| Gormley et al., 2016 [120] | European descent | 59,674 | 8348 | 6332 | 316,078 | 8,045,569 | 38 | 28 | LRP1/STAT6/SDR9C7, PRDM16, FHL5/UFL1, TSPAN2/NGF, TRPM8/HJURP, PHACTR1, MEF2D, SLC24A3, FGF6, C7orf10, PLCE1, KCNK5, ASTN2, MRVI1, HPSE2, CFDP1, RNF213, NRP1, SPR149, JAG1, REST/SPINK2, ZCCHC14, HEY2/NCOA7, WSCD1/NLRP1, GJA1, TGFBR2, ITPK1, ADAMTSL4/ECM1, CCM2L/HCK, YAP1, MED14/USP9X, DOCK4/IMMP2L, CARF, ARMS2/HTRA1, IGSF9B, MPPED2, NOTCH4. | |
| Chen et al., 2017 [125] | Asians (Han Chinese) | 1005 | 1005 | 0 | 0 | 1053 | 642,832 |
0 4c |
0 4c |
- DLG2, GFRA1, UPP2, GPR39.c |
| Chang et al., 2018 [126] | African-Americans | 380 | 123 | 40 | 2129 | 522,471 | 1 | 1 | Near NMUR2 and GLRA1 | |
| Choquet et al., 2021 [127] | Multiethnic (East Asian, African American, Hispanic/Latino, European descent) | 88,526 | NA | NA | NA | 841,795 | Over 10 M | 79 | 45 | JAG1, LEPR, REST, HEY2, NGF, TGFB1, HOXB3, LRP1, PLCE1, HOXB2, HOXB6, YAP1, POLR2A, AMBRA1, TJP2, EP300, LRP4, ARHGAP1, ECM1, HOXB5, HOXB1, MRVI1, ZC3H7B, HTRA1, RPRD2, ZCCHC14, STAT6, MAPKAPK2, C7orf10, KCNK5, C20orf112, ZBTB4, POU4F1, C14orf37, IQCK, C1orf51, LINC00472, BTBD16, MPPED2, YRDC, PRPF3, ARID4A, GPRC5B, THADA, ZNF408, TMEM51, CHRNB1, CHST6, MTF1, MEF2D, INPP5B, CKAP5, RNF213, DGKZ, TSPAN2, CFDP1, KIAA0586, FHL5, ATG13, TIMM9, F2, PSMA3, GPR26, PLEKHA1, TMEM170A, PHB, SLC24A3, L3MBTL2, TARS2, DYRK3, MRPS21, FXN, CHRM4, TMEM91, CHADL, MANEAL, HARBI1, RANGAP1, IER3IP1, UFL1, C1orf122, TRPM8, PHACTR1, ACTR10, NCOA7, C11orf49, PRDM16, SLC45A1-RERE, TMEM51, TSPAN2-NGF, MSL3P1-TRPM8, MIR4791-EFHB, LINC00472-RIMS1, GJA1-HSF2, FXN, ASTN2-LOC100128505, GATA3-SFTA1P, MRGPRE-ZNF195, CALCB, FGF23-FGF6, LRP1-MIR1228, B3GNTL1-METRNL, LINC00310-KCNE2. |
| Hautakangas et al., 2022 [94] | Europeans | 102,084 | 15,055 | 14,624 | 771,257 | 10,843,197 | 123 | 86 | PRDM16, CAMTA1, TMEM51, INPP5B, MACF1, C1orf87, LEPR, RP4-598G3.1, TGFBR3, TSPAN2, ADAMTSL4, MEF2D, RABGAP1L, PLA2G4A, MAPKAPK2, KIF26B, THADA, ANKRD36C, ZEB2, AC064865.1, RNU6-546P, MYO3B, HOXD10, CARF, TRPM8, TGFBR2, ATRIP, HNRNPA3P8, CADM2, C3orf38, ITGB5, GPR149, SEC63P2, SPINK2, ANKDD1B, SSBP2, ZNF474, SNX24, POU4F3, TIGD6|HMGXB3, NKX2–5, NSD1, PHACTR1, PRL, IER3, EHMT2, KCNK5, KRT19P1, FHL5, REV3L, GJA1, PCMT1, SUGCT, MLXIPL, TSPAN12, PTK2B, RP11-573 J24.1, NFIB, RP11-373A6.1, TJP2, ZNF462, ASTN2, EHMT1, RNA5SP299, MLLT10, PLCE1, HPSE2, CNNM2, RBM20, HTRA1, GPR26, INPP5A, MRGPRE, MRVI1, INSC, MPPED2, AMBRA1, RAB3IL1, RBM14-RBM4|RBM4, YAP1, SPATA19, FGF6, PDZRN4, LRP1, ATP2B1, RP11-690 J15.1, NCOR2, LRCH1, RNF219-AS1, COL4A1, RP11-384 J4.2, LRFN5, ARID4A, DLST, IFT43, ITPK1, SERPINA1, ABHD17C, HMOX2, CFDP1, ZCCHC14, SMG6, ZBTB4, HOXB3, RP11-81 K2.1, MRC2, TBC1D16, RNF213, RBBP8, SKOR2, FECH, CACNA1A, SUGP1, B9D2|TMEM91, JAG1, SLC24A3, C20orf112, ZMYND8, MRPS6, RUNX1, AC006547.14, FAM47A, MED14 | |
MO Migraine without aura, MwA Migraine with Aura, M Millions, NA Non Applicable, SNPs Single Nucleotide Polymorphisms
aSignificant association with p-values ≤5 × 10− 5
bSignificant association with p-values ≤5 × 10− 6
cSignificant association with p-values ≤5 × 10− 4