Efficacy for all patients including Kaplan-Meier plots and tabular PFS and OS data by cohort. Outcome for newly diagnosed, MGMT unmethylated patients (cohort A), bevacizumab naïve, recurrent patients (cohorts B, B2 and B3) and bevacizumab refractory, recurrent patients (cohort C) are summarized in panels A, B and C, respectively including Kaplan-Meier plots of PFS (upper) and OS (lower).