Table 3.

Immune Cell Subsets By Cohort and Stratified by Baseline Dexamethasone (Dex) Use

Cohort		A			B/B2/B3
Baseline Dex		Yes	No	P value	Yes	No	P value
Lymphocyte Subset
CD3+	# Patients	11	21		39	50
	Median	1004	1240	NS	523	696	0.0178
CD4+	# Patients	11	21		39	50
	Median	762	910	NS	323	417	0.01404
CD8+	# Patients	11	21		39	50
	Median	344	336	NS	192	238	NS
CD4+ Central Memory	# Patients	9	20		36	45
	Median	197	291	NS	152	199	0.0465
CD4+ Effector Memory	# Patients	9	20		36	45
	Median	72	61	NS	39	43	NS
CD4+ Naïve	# Patients	9	20		36	45
	Median	281	440	NS	102	103	NS
CD4+CD38+	# Patients	9	20		36	45
	Median	459	703	NS	211	273	0.0235
CD4+HLADR+	# Patients	9	20		35	45
	Median	73	85	NS	53	68	0.0130
CD4+ICOS+	# Patients	9	20		35	45
	Median	209	324	0.0477	131	212	0.0015
CD8+ Central Memory	# Patients	9	20		36	45
	Median	27	32	NS	21	28	NS
CD8+ Effector Memory	# Patients	9	20		36	45
	Median	33	43	NS	33	35	NS
CD8+ Naive	# Patients	9	20		36	45
	Median	96	125	NS	49	73	NS
CD8+ CD38+	# Patients	9	20		35	45
	Median	168	243	NS	129	154	NS
CD8+ HLADR+	# Patients	9	20		35	45
	Median	152	97	NS	81	105	NS
CD8+ ICOS+	# Patients	9	20		35	45
	Median	35	41	NS	35	48	0.0151
CD4+ Ki67+	# Patients	8	19		35	43
	Median	13	24	0.0407	8	12	0.0147
CD8+Ki67+	# Patients	8	18		35	42
	Median	7	6	NS	5	7	NS
Day 15 CD4+Ki67+	# Patients	7	14		24	36
	Median	Neg 31	Neg 12	NS	24	23	NS
Day 15 CD8+Ki67+	# Patients	7	13		22	33
	Median	Neg 7	17	NS	0	33	0.0703

Abbreviations: Dex, dexamethasone; Neg, negative; NS not significant