Figure 1.

(a) Right anterior segment showing complete iris hypoplasia. (b) Color fundus photograph lacking foveal reflex and (c) Spectral domain optical coherence tomography (SD-OCT) of the right macula showing complete foveal hypoplasia. (d) Pax6^Sey/+ mouse H and E whole eye sections at postnatal (p) day 60 (top) showing a small eye, lens, and retinal dysplasia, and a thinned P14 corneal epithelium (bottom). (e) Brightfield images (top) and toluidine blue-stained sections (bottom) displaying anterior segment dysgenesis (black arrow), small eye and lens (le) (white arrow), and thickened cornea (co) in 5dpf pax6bSa15822 zebrafish mutant. dpf = days post-fertilization, H and E = hematoxylin and eosin, re = retina