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. 2023 Feb 20;14:945. doi: 10.1038/s41467-023-36234-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — SH-SY5Y and HepG2 cells were treated with NSP11-CoV2 monomers (grey bars) and amyloid fibrils (192 h incubation; light yellow) for 24 h (a, c) and 72 h (b, d). The cells treated with media containing 20 mM sodium phosphate buffer (pH 7.4) were used as a control (dark grey bar; UNT is untreated). Diamond symbols on each bar indicate technical replicates and the error bars represent the SEM of these replicates. ns is a non-significant difference, *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 according to the two-tailed Student’s t-test (no adjustments were made). Correspondingly, for 24 and 72 h treatment on SH-SY5Y cells, the respective p-values of monomer vs. aggregate are 0.8523, 0.7277 (1.4 μM), 0.5860, 0.3560 (5.62 μM), 0.6837, 0.4781 (11.25 μM), 0.4924, 0.0289 (22.5 μM), 0.9899, 0.0779 (45 μM), 0.5091, 0.0050 (90 μM), and 0.3101, 0.0063 (180 μM). For 24 and 72 h treatment on HepG2 cells, the respective p-values of monomer vs. aggregate are 0.1966, 0.0806 (1.4 μM), 0.5306, 0.6118 (5.62 μM), 0.0513, 0.0255 (11.25 μM), 0.1963, 0.0265 (22.5 μM), 0.9911, 0.0897 (45 μM), 0.8042, 0.0001 (90 μM), and 0.8208, <0.0001 (180 μM). The source data are given in the Source Data file.