Table 3.
Summary of quantitative acoustic and kinematic speech measures.
| Group | Case | Syndrome dx | Mean |z|, all features | Mean |z|, shared features | Mean |z|, AOS features | Mean |z|, dysarthria features | Quantitative MSI predominance (AOS + , Dys + ) a |
|---|---|---|---|---|---|---|---|
| MSI− | 1 | lvPPA | 0.64 | 0.56 | 0.68 | 0.87 | — |
| 2 | lvPPA | 0.70 | 0.55 | 1.05 | 0.72 | — | |
| 3 | lvPPA | 1.24 | 1.94 | 0.78 | 0.34 | — | |
| 4 | lvPPA | 1.75 | 2.51 | 1.47 | 0.43 | — | |
| 5 | lvPPA | 0.91 | 0.87 | 1.04 | 0.89 | — | |
| 6 | lvPPA | 0.84 | 1.13 | 0.46 | 0.48 | — | |
| 7 | lvPPA | 1.59 | 2.15 | 1.24 | 0.98 | — | |
| 8 | lvPPA | 1.20 | 1.18 | 1.59 | 0.87 | — | |
| 9 | lvPPA | 1.05 | 0.89 | 1.39 | 1.00 | — | |
| Group M (SD), MSI− | 1.15 (0.93) | 1.31 (1.00) | 1.01 (0.8) | 0.74 (0.57) | — | ||
| MSI+ | 10 | PPAOS | 1.64 | 2.64 | 0.16 | 1.08 | Dys+ |
| 11 | nfvPPA | 2.51 | 3.34 | 2.67 | 2.23 | AOS+ | |
| 12 | CBS | 1.48 | 1.31 | 3.43 | 1.98 | AOS+ | |
| 13 | PSP | 0.95 | 1.26 | 0.32 | 1.20 | Dys+ | |
| 14 | nfvPPA | 1.85 | 2.76 | 1.40 | 1.18 | AOS+ | |
| 15 | PSP | 2.46 | 3.63 | 0.68 | 1.43 | Dys+ | |
| 16 | PPAOS | 2.61 | 4.46 | 1.30 | 0.34 | AOS+ | |
| 17 | PPAOS | 2.16 | 3.60 | 1.01 | 0.77 | AOS+ | |
| 18 | PPAOS | 2.48 | 3.77 | 1.41 | 1.04 | AOS+ | |
| 19 | CBS | 3.76 | 4.74 | 3.52 | 2.21 | AOS+ | |
| 20 | nfvPPA | 3.94 | 4.98 | 3.18 | 8.38 | Dys+ | |
| Group M (SD), MSI+ | 2.64 (1.85) | 3.30 (1.81) | 1.46 (1.29) | 1.38 (1.13) | — | ||
Note. Em dashes indicate data not reported. dx = diagnosis; AOS = apraxia of speech; Dys = dysarthria; lvPPA = logopenic variant primary progressive aphasia; MSI+ = motor-speech–impaired group of individuals with nfvPPA, PPAOS, CBS, or PSP and suspected four-repeat tauopathy pathology; PPAOS = primary progressive apraxia of speech; MSI− = non–motor-speech-impaired group of individuals with logopenic variant primary progressive aphasia; nfvPPA = nonfluent variant primary progressive aphasia; CBS = corticobasal syndrome; PSP = progressive supranuclear palsy.
Predominant impairment based on quantitative speech measures, rated for the MSI+ group only. Predominance determined from a ratio of mean |z|, AOS features to mean |z|, dysarthria features. AOS + (|z|AOS > |z|dys) indicates predominant apraxic impairment; Dys + (|z|dys > |z|AOS) indicates predominant dysarthric impairment.