Table 4.
Summary of auditory-perceptual ratings of motor speech impairment.
| Group | Case | Syndrome dx | SIT score (%) | Overall MSI severity | AOS severity | Dysarthria severity | Auditory-perceptual MSI predominance (AOS + , Dys + ) a |
|---|---|---|---|---|---|---|---|
| MSI− | 1 | lvPPA | 100 | 0.75 | 1 | 0 | — |
| 2 | lvPPA | 99 | 0.25 | 0.25 | 0 | — | |
| 3 | lvPPA | 98 | 0.25 | 0.25 | 0 | — | |
| 4 | lvPPA | 95 | 1 | 1 | 0.5 | — | |
| 5 | lvPPA | 98 | 1 | 1.5 | 0.5 | — | |
| 6 | lvPPA | 96 | 0.25 | 0.25 | 0 | — | |
| 7 | lvPPA | 92 | 0.5 | 0.75 | 0 | — | |
| 8 | lvPPA | 99 | 0.75 | 1.25 | 0.5 | — | |
| 9 | lvPPA | 95 | 1.5 | 1.5 | 0.5 | — | |
| Group M (SD), MSI− | 97.1 (2.6) | 0.69 (0.49) | 0.86 (0.64) | 0.22 (0.43) | — | ||
| MSI+ | 10 | PPAOS | 91 | 0.75 | 0.5 | 0.75 | Dys+ |
| 11 | nfvPPA | 94 | 1.5 | 1.5 | 0.5 | AOS+ | |
| 12 | CBS | 71 | 2 | 2 | 0.25 | AOS+ | |
| 13 | PSP | 97 | 0.25 | 0.25 | 0 | AOS+ | |
| 14 | nfvPPA | 94 | 0.75 | 0.75 | 0.25 | AOS+ | |
| 15 | PSP | 5 | 3 | 0 | 3 | Dys+ | |
| 16 | PPAOS | 100 | 1.5 | 1 | 0.75 | AOS+ | |
| 17 | PPAOS | 98 | 1 | 1 | 0.5 | AOS+ | |
| 18 | PPAOS | 96 | 1 | 0.75 | 0.75 | = | |
| 19 | CBS | 71 | 3 | 2.5 | 3 | Dys+ | |
| 20 | nfvPPA | 2 | 3 | 1.5 | 3 | Dys+ | |
| Group M (SD), MSI+ | 74.3 (36.6) | 1.61 (1.01) | 1.07 (0.81) | 1.18 (1.19) | — | ||
| Healthy controls (HC) | HC1 | — | 100 | 0 | 0 | 0 | — |
| HC2 | — | 100 | 0 | 0 | 0 | — | |
| HC3 | — | 95 | 0 | 0 | 0 | — | |
| HC4 | — | 100 | 0 | 0 | 0 | — | |
| HC5 | — | 100 | 0 | 0 | 0 | — | |
| HC6 | — | 98 | 0 | 0 | 0 | — | |
| HC7 | — | 97 | 0 | 0 | 0 | — | |
| HC8 | — | 97 | 0.5 | 0 | 0.25 | — | |
| HC9 | — | 99 | 0.25 | 0.25 | 0 | — | |
| HC10 | — | 99 | 0 | 0 | 0 | — | |
| Group M (SD), HC | 98.6 (1.6) | 0.08 (0.18) | 0.03 (0.11) | 0.03 (0.11) | — | ||
Note. Em dashes indicate data not reported. dx = diagnosis; SIT = Speech Intelligibility Test; AOS = apraxia of speech; Dys = dysarthria; MSI− = non -motor-speech-impaired group of individuals with logopenic variant primary progressive aphasia; lvPPA = logopenic variant primary progressive aphasia; MSI+ = motor-speech–impaired group of individuals with nfvPPA, PPAOS, CBS, or PSP and suspected four-repeat tauopathy pathology; PPAOS = primary progressive apraxia of speech; nfvPPA = nonfluent variant primary progressive aphasia; CBS = corticobasal syndrome; PSP = progressive supranuclear palsy.
Predominant impairment based on independent auditory-perceptual ratings, rated for the MSI+ group only. Predominance determined from a ratio of mean (across two speech-language pathologist raters) scores for AOS to dysarthria severity. “AOS+” (i.e., mean rated severity AOS > Dys) indicates predominant apraxic impairment; “Dys+” (i.e., mean rated severity Dys > AOS) indicates predominant dysarthric impairment; “=” (i.e., mean rated severity AOS = Dys) indicates no predominance of either apraxia or dysarthria.