Figure 2:

A depiction of the intricacies associated with drug transport at the blood brain barrier. Tight junctions composed of claudins, occludins, and junctional adhesion molecules prevent paracellular transport of macromolecules. The basement membrane provides a scaffold for the interactions between endothelial cells, astrocytes, and pericytes to regulate the permeability and expression of surface receptors. A variety of transporters, efflux pumps, and channels allow for the regulated passage of molecules into the brain interstitial space though remove most drugs efficiently. Created with Biorender.com.