Table 2.
The difference of clinical, hormonal, and metabolic characteristics between IR+/IR-groups in normal weight and obesity/overweight PCOS patents.
| Variable | Normal weight | Obesity/overweight | ||||
|---|---|---|---|---|---|---|
| IR- (n = 351) | IR+ (n = 174) | p | IR- (n = 84) | IR+ (n = 342) | p | |
| Age (y) | 27.11 ± 3.26 | 26.74 ± 3.53 | 0.235 | 28.45 ± 4.15 | 27.39 ± 3.45 | 0.015 |
| BMI (kg/m2) | 20.63 ± 1.57 | 21.89 ± 1.53 | 0.0001 | 26.42 ± 2.82 | 28.05 ± 3.16 | 0.0001 |
| WHR | 0.83 ± 0.07 | 0.86 ± 0.07 | 0.0001 | 0.88 ± 0.10 | 0.93 ± 0.41 | 0.224 |
| WHtR | 46.45 ± 4.03 | 49.59 ± 4.52 | 0.0001 | 55.04 ± 4.54 | 58.60 ± 5.84 | 0.0001 |
| E2 (pmol/l) | 164.21 ± 79.14 | 145.94 ± 73.77 | 0.011 | 160.79 ± 80.87 | 148.19 ± 77.13 | 0.184 |
| T (nmol/l) | 1.17 ± 0.63 | 1.11 ± 0.53 | 0.294 | 1.13 ± 0.59 | 1.23 ± 0.61 | 0.158 |
| LH/FSH ratio | 1.74 ± 1.15 | 1.63 ± 0.96 | 0.270 | 1.42 ± 0.77 | 1.31 ± 0.70 | 0.213 |
| SHBG (nmoL/l) | 60.80 ± 38.18 | 46.94 ± 36.21 | 0.0001 | 39.91 ± 26.19 | 32.00 ± 29.39 | 0.024 |
| FAI | 2.69 ± 70 | 3.64 ± 3.62 | 0.001 | 3.74 ± 2.89 | 5.80 ± 4.41 | 0.0001 |
| FGS (mmol/l) | 5.24 ± 0.64 | 5.95 ± 0.99 | 0.0001 | 5.27 ± 0.78 | 6.20 ± 1.19 | 0.0001 |
| F2h (mmol/l) | 5.64 ± 1.17 | 6.68 ± 2.00 | 0.0001 | 6.50 ± 1.62 | 7.68 ± 2.27 | 0.0001 |
| FIN (μIU/ml) | 7.42 ± 2.40 | 16.09 ± 7.58 | 0.0001 | 8.28 ± 2.47 | 21.22 ± 8.14 | 0.0001 |
| FI2h (μIU/ml) | 56.46 ± 46.38 | 114.38 ± 98.81 | 0.0001 | 64.80 ± 37.11 | 150.68 ± 156.78 | 0.0001 |
| CHO (mmol/l) | 4.14 ± 0.71 | 4.23 ± 0.72 | 0.194 | 4.29 ± 0.79 | 5.64 ± 2.80 | 0.588 |
| TG (mmol/l) | 0.99 ± 0.53 | 1.56 ± 1.40 | 0.0001 | 1.40 ± 0.77 | 1.95 ± 1.26 | 0.0001 |
| HDL-C (mmol/l) | 1.39 ± 0.28 | 1.29 ± 0.32 | 0.0001 | 1.25 ± 0.28 | 1.10 ± 0.21 | 0.0001 |
| LDL-C (mmol/l) | 2.82 ± 8.92 | 2.44 ± 0.66 | 0.582 | 2.59 ± 0.64 | 2.82 ± 2.00 | 0.306 |
| LP (a) (mg/l) | 143.79 ± 137.80 | 148.47 ± 151.33 | 0.724 | 204.50 ± 239.27 | 140.42 ± 157.10 | 0.003 |
| VAI | 1.45 ± 1.20 | 2.90 ± 3.61 | 0.0001 | 2.36 ± 1.52 | 3.90 ± 3.30 | 0.0001 |
| LAP | 20.93 ± 31.73 | 38.41 ± 40.60 | 0.0001 | 53.27 ± 52.23 | 74.38 ± 57.88 | 0.002 |
Note: values are expressed as mean ± SD. IR: insulin resistance; BMI: body mass index; WHR: waist-to-hip ratio; WHtR: waist-to-height ratio; E2: estradiol; T: testosterone; LH: luteinizing hormone; FSH: follicle-stimulating hormone; SHBG: sex hormone-binding globulin; FAI: free androgen index; FGS: fasting glucose; FIN: fasting insulin; F2h: 2-hour postprandial blood glucose; FI2h: 2-hour postprandial blood insulin; CHO: total cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; LP (a): lipoprotein (a); VAI: visceral adiposity index; LAP: lipid accumulation product.