Table 3.
The difference of clinical, hormonal, and metabolic characteristics between FAI+/FAI- groups in normal weight and obesity/overweight PCOS patents.
| Variable | Normal weight | Obesity/overweight | ||||
|---|---|---|---|---|---|---|
| FAI- (n = 490) | FAI+ (n = 35) | p | FAI- (n = 288) | FAI+ (n = 138) | p | |
| Age (y) | 27.09 ± 3.32 | 25.54 ± 3.47± | 0.008 | 27.66 ± 3.58 | 27.47 ± 3.70 | 0.621 |
| BMI (kg/m2) | 20.98 ± 1.65 | 22.03 ± 1.47 | 0.0001 | 27.49 ± 3.04 | 28.23 ± 3.34 | 0.023 |
| WHR | 0.84 ± 0.07 | 0.87 ± 0.06 | 0.015 | 0.93 ± 0.44 | 0.91 ± 0.10 | 0.573 |
| WHtR | 47.33 ± 4.41 | 49.80 ± 4.38 | 0.001 | 57.43 ± 5.77 | 58.87 ± 5.71 | 0.016 |
| E2 (pmol/l) | 157.22 ± 77.69 | 171.21 ± 79.40 | 0.304 | 147.71 ± 80.35 | 156.74 ± 72.64 | 0.262 |
| T (nmol/l) | 1.10 ± 0.56 | 1.91 ± 0.64 | 0.0001 | 0.97 ± 0.48 | 1.71 ± 0.52 | 0.0001 |
| LH/FSH ratio | 1.70 ± 1.09 | 1.85 ± 1.07 | 0.429 | 1.30 ± 0.73 | 1.40 ± 0.67 | 0.162 |
| SHBG (nmoL/l) | 58.84 ± 38.00 | 19.37 ± 8.67 | 0.0001 | 41.04 ± 32.39 | 18.14 ± 7.15 | 0.0001 |
| HOMA-IR | 2.48 ± 1.61 | 3.56 ± 2.81 | 0.0001 | 4.61 ± 2.68 | 6.25 ± 3.27 | 0.0001 |
| FGS (mmol/l) | 5.48 ± 0.85 | 5.42 ± 0.64 | 0.691 | 5.91 ± 1.13 | 6.25 ± 1.25 | 0.004 |
| F2h (mmol/l) | 5.91 ± 1.47 | 7.03 ± 2.40 | 0.0001 | 7.16 ± 2.09 | 8.04 ± 2.33 | 0.0001 |
| FIN (μIU/ml) | 9.97 ± 5.63 | 14.74 ± 11.41 | 0.0001 | 17.10 ± 8.36 | 21.93 ± 9.40 | 0.0001 |
| FI2h (μIU/ml) | 70.83 ± 62.70 | 143.14 ± 147.35 | 0.0001 | 119.92 ± 161.40 | 162.50 ± 99.70 | 0.004 |
| CHO (mmol/l) | 4.17 ± 0.72 | 4.14 ± 0.68 | 0.785 | 5.85 ± 4.92 | 4.38 ± 0.86 | 0.485 |
| TG (mmol/l) | 1.14 ± 0.93 | 1.55 ± 1.16 | 0.014 | 1.79 ± 1.27 | 1.93 ± 1.00 | 0.260 |
| HDL-C (mmol/l) | 1.36 ± 0.29 | 1.30 ± 0.33 | 0.249 | 1.16 ± 0.25 | 1.07 ± 0.19 | 0.0001 |
| LDL-C (mmol/l) | 2.72 ± 7.55 | 2.38 ± 0.60 | 0.791 | 2.78 ± 2.16 | 2.74 ± 0.73 | 0.823 |
| LP (a) (mg/l) | 146.00 ± 143.74 | 135.67 ± 120.51 | 0.682 | 160.05 ± 192.52 | 138.4 ± 142.15 | 0.240 |
| VAI | 1.87 ± 2.34 | 2.85 ± 2.87 | 0.018 | 3.39 ± 3.27 | 4.04 ± 2.66 | 0.043 |
| LAP | 25.57 ± 35.19 | 42.91 ± 41.28 | 0.006 | 66.07 ± 54.79 | 78.80 ± 61.69 | 0.031 |
Note: values are expressed as mean ± SD. FAI: free androgen index; BMI: body mass index; WHR: waist-to-hip ratio; WHtR: waist-to-height ratio; E2: estradiol; T: testosterone; LH: luteinizing hormone; FSH: follicle-stimulating hormone; SHBG: sex hormone-binding globulin; HOMA-IR: homeostasis model assessment-insulin resistance; FGS: fasting glucose; FIN: fasting insulin; F2h: 2-hour postprandial blood glucose; FI2h: 2-hour postprandial blood insulin; CHO: total cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; LP (a): lipoprotein (a); VAI: visceral adiposity index; LAP: lipid accumulation product.