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Viability of TSCC cells after various treatments. (a-c) Inhibition of the proliferation of Cal27 and Cal27/CDDP cells following treatment with PB, 5-Fu, and CDDP. (d) A combination of PB and PF exerted synergistic cytotoxic effects in Cal27 and Cal27/CDDP cells. TSCC, tongue squamous cell carcinoma; PB, plumbagin; 5-Fu, 5-fluorouracil; and PF, cisplatin plus 5-fluorouracil.
