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. 2023 Feb 13;2023:8306514. doi: 10.1155/2023/8306514

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Copyright © 2023 Shu-Ting Pan et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Combined treatment with PB and PF inhibited TSCC xenograft tumor growth in vivo. (a-b) Cal27/CDDP-derived xenograft models via subcutaneous injection into BALB/c nude mice. (c) Tumor weights in the PB + PF group were significantly lower than those in the control group. (d) Tumor volumes in the PB + PF group were significantly lower than those in the control group. (e) No significant changes in body weight were observed in the PB + PF group compared with the control group. (f) Ki67 expression in the PB + PF group was significantly lower than that in the control group. (g) H and E staining verified that the PB + PF group did not induce toxicity in major organs (n = 6/group). PB, plumbagin; PF, cisplatin plus 5-fluorouracil; and TSCC, tongue squamous cell carcinoma.