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. 2023 Feb 2;29(2):473–482. doi: 10.1038/s41591-022-02179-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a,b, Forest plot analysis of PFS (a) and OS (b) in prespecified and post-hoc (smoking status) subgroups in the ITT population for patients receiving serplulimab plus chemotherapy (n = 368) versus placebo plus chemotherapy (n = 183). PFS was assessed in accordance with RECIST v1.1 by the IRRC. The Cox proportional hazards model with Efron’s method of tie handling was used to assess the magnitude of the treatment difference between groups. Sex was recorded by the investigators according to the identity information provided by the patients.