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. 2023 Feb 2;29(2):483–492. doi: 10.1038/s41591-022-02194-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A total of 1,790 patients with POI were recruited for the initial assessment, during which serum tests, pelvic ultrasounds and medical records were assessed for each participant. WES was performed in 1,030 patients who met inclusion criteria. *The inclusion criteria were based on 2016 ESHRE guidelines for POI. E2, estrogen.