Table 2.
Clinical characteristics of the GC and NGC participants in the independent external validation dataset.
| Clinical indexes | Independent external validation dataset |
||
|---|---|---|---|
| GC (n = 294) | NGC (n = 521) | P value | |
| Subgroup information | TNM stage I = 74; II = 113; III = 90; IV = 17 | HC = 88; SG = 257; AG = 176 | N/A |
| Age (Years) | 62.28 ± 9.43 | 61.55 ± 8.87 | 0.27 |
| Sex (Female/Male) | 87/207 | 176/345 | 0.22 |
| BMI (kg/m2) | 22.98 ± 3.41 | 22.66 ± 3.06 | 0.16 |
| Smoking (Yes/No) | 92/202 | 139/382 | 0.16 |
| Drinking (Yes/No) | 90/204 | 184/337 | 0.35 |
| HP (Positive/Negative/Unknown) | 53/47/194 | 88/90/343 | 0.57 |
| Family history (Yes/No) | 39/255 | N/A | N/A |
| Pathological type (Adenocarcinoma/Others/Unknown) | 281/9/4 | N/A | N/A |
| Tumour size (≤5 cm/＞5 cm/Unknown) | 174/111/9 | N/A | N/A |
| Tumour location (U/M/L/W/Unknown) | 69/63/151/7/4 | N/A | N/A |
| Grade of differentiation (High/Medium + Medium-low/Low/Unknown) | 23/120/147/4 | N/A | N/A |
| TNM type (I/II/III/IV) | 74/113/90/17 | N/A | N/A |
| HER2 (0/1/2/3/Unknown) | 87/74/34/24/75 | N/A | N/A |
| MMR (dMMR/pMMR/Unknown) | 17/166/111 | N/A | N/A |
| Lauren type (Intestinal/Diffuse/Mixed/Unknown) | 36/36/43/179 | N/A | N/A |
| Nerve invasion (Yes/No/Unknown) | 92/52/150 | N/A | N/A |
| Vascular tumour thrombus (Yes/No/Unknown) | 68/78/148 | N/A | N/A |
| CEA (ng/ml) | (n = 263) 5.40 ± 23.06 |
(n = 297) 1.63 ± 1.27 |
0.009 |
| CA242 (U/ml) | (n = 230) 29.13 ± 89.52 |
(n = 171) 4.51 ± 3.82 |
<0.0001 |
| CA724 (U/ml) | (n = 252) 11.15 ± 30.09 |
(n = 167) 2.79 ± 2.07 |
<0.0001 |
| AFP (ng/ml) | (n = 264) 12.97 ± 94.21 |
(n = 288) 2.54 ± 1.70 |
0.073 |
| CA125 (U/ml) | (n = 226) 17.19 ± 35.82 |
(n = 283) 11.98 ± 8.09 |
0.033 |
| CA19-9 (U/ml) | (n = 239) 41.59 ± 127.84 |
(n = 286) 14.42 ± 10.08 |
0.001 |
| CA50 (U/ml) | (n = 144) 28.98 ± 73.52 |
(n = 167) 8.56 ± 6.38 |
0.001 |
| Ferritin (ng/ml) | (n = 129) 102.85 ± 136.16 |
(n = 182) 42.79 ± 73.26 |
<0.0001 |
CA, Carbohydrate antigen; CEA, Carcinoembryonic antigen; GC, Gastric cancer; HP, helicobacter pylori; NGC, Non-gastric cancer.