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. 2023 Feb 20;6:199. doi: 10.1038/s42003-023-04561-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Barplots show the overlap rates of MIBC and NMIBC enhancers with FRA1 and FLI1 peaks. b Regulatory network denoting the transcription factors, FRA1 and FLI1 and their target genes involved in epithelium migration, cell junction organization and regulation of epithelial cell proliferation. For simplicity similar terms were left out of the visualized image (please see Supplementary Data 3, ‘epithelium migration’ and ‘cell junction organization’, and ‘regulation of epithelial cell proliferation’ related terms are highlighted in yellow). c, d Plots showing the downregulation of FRA1 (c) and FLI1 (d) at mRNA and protein level. Top panels display the relative mRNA levels, bottom panels show the western blot images. e, f Barplots display the relative mRNA levels of FLOT1 (e) and MAP4K4 (f) (top panels). Snapshots showing H3K27ac, FRA1 and FLI1 signals at the MIBC enhancers regulating FLOT1 and MAP4K4 genes (bottom panels). Scale of the snapshots are adjusted to 25. Error bars show the standard deviation of two biological replicates. Each biological replicate is analyzed in three technical replicates.* p-value < 0.05, **p-value < 0.01.