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. 2023 Feb 7;14:1130670. doi: 10.3389/fphar.2023.1130670

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Copyright © 2023 Alshehri and Alorfi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathological liver evaluation in (A) control rats, (B) rats injected with vancomycin only, liver-Intralobular mononuclear inflammatory infiltrations (white arrow), and Mallory bodies (black arrow) due to degeneration of hepatocytes and increased vacuolation in the cytoplasm of hepatocytes appeared as indistinct clear vacuoles (black arrow) indicate glycogen infiltration and (C) rats injected with vancomycin and resveratrol, liver-showed marked improved on a mononuclear cell, and decrease number of mononuclear inflammatory infiltrates (white arrow) and decrease of Mallory bodies (black arrow).