Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The role of TMAO in onset and progression of atherosclerosis. High circulating levels of TMAO inhibited RCT, and accumulated cholesterol, which promoted the formation of foam cells; TMAO induced inflammatory responses, resulting in increased production of pro-inflammatory cytokines such as TNF-α and IL-1B; TMAO caused endothelial dysfunction and platelet activation, and ultimately contributed to the development of atherosclerosis.
