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. 2022 Dec 20;25(3):706–720. doi: 10.1007/s12094-022-02976-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — ZBTB4 inhibited EC cell line proliferation, migration, and invasion via specificity protein axis. Overexpression of miR-576 could inhibit the expression of ZBTB4 but could increase Sp1 and Sp-regulated genes (VEGF, survivin, CCND1) expression. Knockdown miR-576 did the opposite effect. The inhibition of ZBTB4 could increase the expression of Sp1 and Sp-regulated gene products