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. 2023 Feb 20;14(2):144. doi: 10.1038/s41419-023-05677-4

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Relative expression of SHMT2 and SHMT1 in ccRCC specimens and controls based on the TCGA database. B qRT-PCR analysis was performed to evaluate the SHMT2 mRNA levels in 12 pairs of ccRCC tissues and controls. C Western blot analysis was performed to evaluate the SHMT2 protein levels in 12 pairs of ccRCC tissues and controls. β-actin expression was detected as a loading control. T meaned tumors and N meaned paired controls. D TMA IHC scores showing that high, middle and low SHMT2 expression were observed in 21, 13, and 41 of the 75 tumor specimens. The corresponding numbers were 1, 21, and 53 in the 75 paired control tissues (left). Representative IHC staining of SHMT2 protein in human ccRCC tissues (right). E Overall survival curves of ccRCC patients with different SHMT2 expression levels based on the GEPIA database. *P < 0.05, **P < 0.01, ****P < 0.0001.