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. 2023 Feb 7;11:1075917. doi: 10.3389/fcell.2023.1075917

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Copyright © 2023 Yu, Yang, Chen, Wang, Guo, Liu, Li and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Doxorubicin-induced cardiomyocyte pyroptosis. Schematic representation of doxorubicin-induced cardiomyocyte pyroptosis. Doxorubicin recruits IGF2BP and increases NLRP3 expression by upregulating TINCR, which in turn activates caspase1, cleaves GMDSD-N, and releases IL-1β, IL-18. Doxorubicin activates Bnip3 in mitochondria, which activates caspase3 and causes GSDME-dependent pyroptosis. Bnip3, BCL2-interacting protein three; TINCR, terminal differentiation-induced NcRNA; NLRP3, NOD-, LRR-, and pyrin domain-containing protein three; GSDME, gasdermin E; GSDMD, gasdermin D; IGF2BP1, insulin-like growth factor 2 mRNA-binding protein 1.