TABLE 3.

Current synthetic inhibitory oligonucleotides in clinical and preclinical trials.

ODN type	Drug name	Disease	Status	Reference
AS-ODN	Vitravene	CMV retinitis	FDA approved	Roehr (1998)
AS-ODN	Inotersen	Hereditary transtherthyretin-mediated amyloidosis	FDA approved	Keam (2018)
AS-ODN	ISIS 2922	CMV-induced retinitis in AIDS	Phase III	Cinatl et al. (2000)
AS-ODN	ISIS 2302	Ulcerative colitis, Rheumatoid arthritis	Phase III	Scarozza et al. (2019)
AS-ODN	ISIS 104838	Rheumatoid arthritis	Phase III	Narayanan et al. (2018)
AS-ODN	EPI-2010	Asthma	Phase II	Ball et al. (2004)
AS-ODN	TPI ASM8	Allergic inflammation	Phase II	Gauvreau et al., 2011; Imaoka et al., 2011
AS-ODN	Gem92	HIV	Phase I	Zheng (1999)
AS-ODN	AR 177	HIV	Phase I	Smart (1996)
AS-ODN	LNA-AS-ODN	Osteoarthritis	Pre-clinical	Nakamura et al. (2019)
Aptamer	Pegaptanib	Neovascular AMD	FDA approved	Chapman and Beckey (2006)
Aptamer	Macugen	Age-Related Macular Degeneration	FDA approved	Vavvas and D'Amico (2006)
Aptamer	ARC1905	Age-Related Macular Degeneration	Phase I	Leung and Landa (2013)
Aptamer	Fovista	Age-Related Macular Degeneration	Phase III	Tolentino et al. (2015)
Aptamer	Zimura	Geographic Atrophy Macular Degeneration	Phase II	Jaffe et al. (2021)
Aptamer	AS1411	Acute Myeloid Leukemia	Phase II	Yazdian-Robati et al. (2020)
Aptamer	NOX-E36	Chronic Inflammatory Diseases	Phase I	Baeck et al. (2012)
Aptamer	GP-120	HIV	Pre-clinical	Wang et al. (2019)
Aptamer	TLR4	brain damage after cerebral hemorrhage	Pre-clinical	Fernández et al. (2018)
Aptamer	IL-23	brain inflammation	Pre-clinical	Shahdadi Sardou et al. (2020)
Aptamer	RA10-6	Synovial inflammation in mice with osteoarthritis	Pre-clinical	Chen et al. (2011)
Aptamer	Apt-TNF-α	ALI, ALF	Pre-clinical	Lai W. Y et al. (2019)
iSup-ODN	STA05F	SLE, SIRS	Pre-clinical	Dong et al. (2005); Yazar et al. (2020)
iSup-ODN	A151	SLE, Atherosclerosis	Pre-clinical	Cheng et al. (2008)
iSup-ODN	ODN1411	RA	Pre-clinical	Sacre et al. (2016)
iSup-ODN	MT01	Periodontitis	Pre-clinical	Shen et al. (2012)
iSup-ODN	MS19	Sepsis	Pre-clinical	Gao et al. (2017)
iSup-ODN	rODN M1	IAV-induced acute ALI	Pre-clinical	Meng et al. (2017)
iSup-ODN	YW002	Alcoholic hepatitis	Pre-clinical	Wang et al. (2012)
iSup-ODN	ODN IRS954	SLE	Pre-clinical	Barrat et al. (2005)