Table 2.
Targets known to be regulated by ATF4.
| Product of ATF4 target gene | Brief description | Regulation | References by species |
|---|---|---|---|
| DDIT3/CHOP | bZIP transcription factor | Upregulation | Human: Bruhat et al. (2007), Shimizu et al. (2013), Wang et al. (2015), Lin et al. (2018), Bagheri-Yarmand et al. (2019), Örd et al. (2021). Mouse: Chérasse et al. (2007), Han et al. (2013), Farooq et al. (2022). |
| ASNS | Asparagine Synthetase | Upregulation | Human: Chen et al. (2004), Su and Kilberg (2008), Gjymishka et al. (2009), Burton et al. (2020), Örd et al. (2021). Mouse: Freundt et al. (2018). |
| TRIB3 | Pseudokinase | Upregulation | Human: Su and Kilberg (2008), Carraro et al. (2010), Wang et al. (2015). Rat: Bromati et al. (2011). Mouse: Carraro et al. (2010), Han et al. (2013). |
| ATF3 | bZIP transcription factor | Upregulation | Human: Pan et al. (2007), Lee et al. (2013). Rat: Zhou and Pan (2011). Mouse: Han et al. (2013), Sasaki et al. (2020). |
| VEGFA | Vascular Endothelial Growth Factor | Upregulation | Human: Su and Kilberg (2008), Wang et al. (2012), Kim et al. (2020). Mouse: Oskolkova et al. (2008), Freundt et al. (2018). |
| MTHFD2 | Mitochondrial bifunctional dehydrogenase | Upregulation | Human: Wang et al. (2015), Örd et al. (2021). Mouse: Han et al. (2013), Freundt et al. (2018). |
| SLC7A11 | Cystine/glutamate antiporter xCT | Upregulation | Human: Wang et al. (2015), Örd et al. (2021), Ferguson et al. (2022). Mouse: Han et al. (2013). |
| FGF21 | Fibroblast growth factor | Upregulation | Human: Tao et al. (2022). Mouse: Örd et al. (2018), Sasaki et al. (2020). |
| AARS | Aminoacyl-tRNA synthetase | Upregulation | Mouse: Han et al. (2013), Shan et al. (2016), Freundt et al. (2018). |
| CEBPB | bZIP transcription factor | Upregulation | Human: Chen et al. (2005), Wang et al. (2015). Mouse: Guo et al. (2019). |
| CHAC1 | Glutathione-specific gamma-glutamylcyclotransferase | Upregulation | Human: Crawford et al. (2015), Wang et al. (2015). Mouse: Juliana et al. (2018). |
| DDIT4/REDD1 | Negative regulator of mTOR | Upregulation | Human: Wang et al. (2015), Örd et al. (2021), Han et al. (2021). |
| GPT2 | Mitochondrial glutamic--pyruvic transaminase | Upregulation | Human: Wang et al. (2015). Mouse: Han et al. (2013), Juliana et al. (2018). |
| LC3B/ MAP1LC3B | Autophagy protein | Upregulation | Human: Shen et al. (2015), Zhong et al. (2022). Rat: Cai et al. (2022). |
| PPP1R15A /GADD34 | Protein phosphatase 1 adaptor for eIF2 | Upregulation | Human: Wang et al. (2015). Mouse: Han et al. (2013), Sasaki et al. (2020). |
| PSAT1 | Phosphoserine aminotransferase | Upregulation | Human: Gao et al. (2017), Örd et al. (2021). Mouse: Freundt et al. (2018). |
| WARS | Aminoacyl-tRNA synthetase | Upregulation | Human: Wang et al. (2015). Mouse: Han et al. (2013), Shan et al. (2016). |
| ALDH18A1 | Mitochondrial aldehyde dehydrogenase | Upregulation | Mouse: Han et al. (2013), Freundt et al. (2018). |
| ATG7 | Autophagy related protein | Upregulation | Human: Zhong et al. (2022). Rat: Cai et al. (2022). |
| BGLAP (Osteocalcin) | Bone gamma-carboxyglutamic acid-containing protein | Upregulation | Mouse: Tominaga et al. (2008), Yu et al. (2009). |
| CDSN | Corneodesmosin | Upregulation | Mouse: Han et al. (2013), Sasaki et al. (2020). |
| EIF2S2 | eIF2 subunit (eIF2β) | Upregulation | Mouse: Han et al. (2013), Freundt et al. (2018). |
| EPRS | Aminoacyl-tRNA synthetase | Upregulation | Mouse: Han et al. (2013), Shan et al. (2016). |
| FGF19 | Fibroblast growth factor | Upregulation | Human: Shimizu et al. (2013), Lang et al. (2021). |
| GARS | Aminoacyl-tRNA synthetase | Upregulation | Mouse: Han et al. (2013), Shan et al. (2016). |
| GDF15 | Growth/differentiation factor | Upregulation | Human: Wang et al. (2015), Li A. et al. (2021). |
| HERPUD1 | Homocysteine-responsive ER-resident ubiquitin-like domain | Upregulation | Human: Wang et al. (2015). Mouse: Freundt et al. (2018). |
| HSPA5 | Molecular chaperone | Upregulation | Human: Wang et al. (2015). Mouse: Han et al. (2013). |
| IARS | Aminoacyl-tRNA synthetase | Upregulation | Mouse: Han et al. (2013), Shan et al. (2016). |
| JDP2 | bZIP transcription factor | Upregulation | Human: Wang et al. (2015). Mouse: Freundt et al. (2018). |
| KDM7A | Histone lysine demethylase | Upregulation | Human: Wang et al. (2015). Mouse: Han et al. (2013). |
| LARS | Aminoacyl-tRNA synthetase | Upregulation | Mouse: Han et al. (2013), Shan et al. (2016). |
| miR-552 | Micro RNA 552 | Upregulation | Human: Feng et al. (2022). Mouse: Feng et al. (2022). |
| MKNK2 | MAP kinase-interacting serine/threonine-protein kinase | Upregulation | Human: Wang et al. (2015), Bagheri-Yarmand et al. (2019). |
| NARS | Aminoacyl-tRNA synthetase | Upregulation | Mouse: Han et al. (2013), Shan et al. (2016). |
| PTGS2/COX2 | Prostaglandin-endoperoxide synthase | Upregulation | Human: Xiao et al. (2011), Di et al. (2018). |
| SARS | Aminoacyl-tRNA synthetase | Upregulation | Mouse: Han et al. (2013), Shan et al. (2016). |
| SQSTM1/P62 | Autophagosome cargo protein | Upregulation | Rat: Cai et al. (2022). Mouse: Han et al. (2013). |
| VARS | Aminoacyl-tRNA synthetase | Upregulation | Mouse: Han et al. (2013), Shan et al. (2016). |
| VLDLR | Very-low-density-lipoprotein receptor | Upregulation | Human: Wang et al. (2015). Mouse: Han et al. (2013). |
| YARS | Aminoacyl-tRNA synthetase | Upregulation | Mouse: Han et al. (2013), Shan et al. (2016). |