Table 1.

Concentration of amino acids in the MDA-MB-231 ​cells. Data is shown as mean difference of treated and untreated samples in a 95% (CI) and standard error (SE); n ​= ​3.

Amino acid	Mean difference (μmol/L) at 95% CI			SE
	CDDP vs. Untreated	PtNPs-10 vs. Untreated	PtNPs-40 vs. Untreated
Asp	39.15 (-9.62 to 87.92)	-118.00 (-166.77 to -69.23)∗∗∗	-40.81 (-89.58 to 7.96)	15.23
Thr	23.83 (8.99–38.68)∗∗	-22.29 (-37.14 to -7.44)∗∗	-6.71 (-21.56 to 8.14)	4.64
Ser	53.09 (39.79–66.41)∗∗∗	-2.98 (-16.29 to 10.34)	2.06 (-11.26 to 15.37)	4.16
Glu	69.10 (-23.94 to 162.14)	-163.26 (-265.30 to -70.22)∗∗	-64.92 (-157.96 to 28.12)	29.05
Pro	-1.19 (-34.96 to 32.57)	6.45 (-27.31 to 40.22)	4.51 (-29.25 to 38.27)	10.54
Gly	37.96 (-56.60 to 132.51)	-150.52 (-254.07 to -55.96)∗∗	-47.44 (-141.00 to 47.12)	29.53
Ala	43.60 (2.93–84.28)∗	-86.79 (-127.46 to -46.11)∗∗∗	-34.32 (-74.00 to 6.35)	12.70
Cys	-0.52 (-142.01 to 140.97)	64.14 (-77.35 to 205.63)	1.04 (-140.45 to 142.53)	44.18
Val	24.55 (-30.98 to 80.08)	-85.38 (-140.90 to -29.84)∗∗	-42.30 (-97.83 to 13.23)	17.34
Met	6.47 (-56.41 to 69.36)	20.91 (-41.97 to 83.80)	-1.80 (-64.68 to 61.09)	19.64
Ile	49.30 (-7.84 to 106.44)	-61.57 (-118.71 to -4.43)∗	-0.30 (-57.44 to 56.84)	17.84
Leu	20.76 (-13.61 to 55.13)	-98.49 (-132.86 to -64.12)∗∗∗	-41.30 (-75.67 to - 6.93)∗	10.73
Tyr	23.48 (-28.39 to 75.36)	-24.43 (-73.30 to 27.45)	-16.86 (-68.73 to 35.02)	16.20
Phe	24.43 (-11.87 to 60.73)	-36.03 (-72.33 to 0.27)	-32.06 (-68.26 to 4.25)	11.34
His	186.35 (24.27–348.43)∗	-37.52 (-199.60 to 124.56)	-71.25 (-233.32 to 90.83)	50.61
Lys	263.44 (-22.55 to 747.42)	-270.80 (-754.79 to 213.18)	-163.44 (-647.43 to 320.54)	151.13
Arg	133.40 (-548.58 to 815.37)	-569.07 (-1251.05 to 112.90)	-231.78 (-913.76 to 450.19)	212.96

Negative sign in front of the mean indicates a decrease in the concentration of the amino acid in the treated sample compared to the control.

∗p ​< ​0.05, ∗∗p ​< ​0.01, ∗∗∗p ​< ​0.001.