Table 2.

Concentration of amino acids in the tumors. Data is shown as mean difference of treated and untreated samples in a 95% (CI) and standard error (SE); n ​= ​9.

Amino acid	Mean difference (g/kg) at 95% CI			SE
	CDDP vs. Untreated	PtNPs-10 vs. Untreated	PtNPs-40 vs. Untreated
Asp	-2.84 (-4.59 to -1.09)∗∗∗	-0.22 (-1.97 to 1.52)	-0.48 (-2.23 to 1.27)	0.64
Thr	-1.03 (-1.44 to -0.62)∗∗∗	-0.29 (-0.70 to 0.11)	-0.50 (-0.91 to -0.09)∗	0.15
Ser	-1.19 (-1.74 to -0.63)∗∗∗	-0.23 (-0.78 to 0.33)	-1.09 (-1.64 to -0.53)∗∗∗	0.20
Glu	-3.70 (-6.02 to -1.37)∗∗∗	-0.28 (-2.61 to 2.04)	-0.61 (-2.94 to 1.71)	0.86
Pro	-1.56 (-3.42 to 0.30)	-0.86 (-2.72 to 1.00)	0.31 (-1.55 to 2.17)	0.69
Gly	-1.95 (-3.16 to -0.73)∗∗∗	-0.76 (-1.98 to 0.45)	0.10 (-1.11 to 1.31)	0.45
Ala	-1.62 (-2.87 to -0.36)∗∗	-0.22 (-1.47 to 1.03)	0.06 (-1.19 to 1.31)	0.46
Cys	-0.21 (-0.41 to -0.01)∗	−0.21 (-0.41 to -0.01)∗	-0.05 (-0.25 to 0.16)	0.07
Val	-1.90 (-2.94 to -0.85)∗∗∗	-0.35 (-1.39 to 0.70)	-0.34 (-1.39 to 0.71)	0.39
Met	-0.52 (-0.78 to -0.27)∗∗∗	-0.11 (-0.37 to 0.14)	-0.21 (-0.47 to 0.04)	0.10
Ile	-1.12 (-1.86 to -0.38)∗∗	0.08 (-0.66 to 0.82)	-0.16 (-0.91 to 0.58)	0.27
Leu	-2.51 (-4.01 to -1.01)∗∗∗	-0.41 (-1.91 to 1.09)	-0.97 (-2.47 to 0.53)	0.55
Tyr	-1.07 (-1.64 to -0.49)∗∗∗	-0.19 (-0.77 to 0.39)	-0.25 (-0.83 to 0.32)	0.21
Phe	-1.21 (-2.17 to -0.25)∗∗	-0.11 (-1.07 to 0.85)	-0.07 (-1.03 to 0.89)	0.35
His	-0.82 (-1.18 to -0.45)∗∗∗	-1.87 (-2.24 to -1.50)∗∗∗	-1.73 (-2.10 to -1.36)∗∗∗	0.14
Lys	-2.44 (-4.72 to -0.17)∗	0.82 (-1.45 to 3.10)	1.34 (-0.93 to 3.62)	0.84
Arg	-3.10 (-6.48 to 0.29)	1.36 (-2.03 to 4.74)	3.87 (0.49–7.26)∗	1.25

Negative sign in front of the mean indicates a decrease in the concentration of the amino acid in the treated sample compared to the control.

∗p ​< ​0.05, ∗∗p ​< ​0.01, ∗∗∗p ​< ​0.001.