Table 3.
Concentration of amino acids in the liver. Data is shown as mean difference of treated and untreated samples in a 95% (CI) and standard error (SE); n = 9.
| Amino acid | Mean difference (g/kg) at 95% CI |
SE | |||
|---|---|---|---|---|---|
| Untreated vs. NTC | CDDP vs. Untreated | PtNPs-10 vs. Untreated | PtNPs-40 vs. Untreated | ||
| Asp | 1.29 (-1.10 to 3.68) | -0.14 (-2.23 to 2.25) | -1.37 (-3.76 to 1.02) | 0.63 (-1.76 to 3.02) | 0.84 |
| Thr | 0.98 (0.04–1.93)∗ | -0.83 (-1.77 to 0.11) | -0.10 (-1.04 to 0.84) | 0.90 (-0.04 to 1.84) | 0.33 |
| Ser | 0.37 (-0.66 to 1.40) | -0.38 (-1.41 to 0.66) | -0.35 (-1.38 to 0.69) | 0.78 (-0.25 to 1.82) | 0.36 |
| Glu | 1.40 (-1.46 to 4.26) | 0.02 (-2.85 to 2.88) | -1.61 (-4.47 to 1.26) | 0.83 (-2.03 to 3.69) | 1.00 |
| Pro | 0.16 (-1.35 to 1.67) | -0.06 (-1.57 to 1.46) | -1.49 (-3.00 to 0.03) | -0.84 (-2.35 to 0.67) | 0.53 |
| Gly | 0.64 (-0.62 to 1.90) | 0.06 (-1.20 to 1.32) | -0.53 (-1.79 to 0.73) | 0.26 (-1.00 to 1.52) | 0.44 |
| Ala | 1.05 (-0.65 to 2.78) | -0.15 (-1.86 to 1.55) | -1.02 (-2.73 to 0.68) | 0.19 (-1.52 to 1.89) | 0.60 |
| Cys | -0.05 (-0.17 to 0.08) | 0.06 (-0.07 to 0.19) | -0.02 (-0.15 to 0.10) | 0.03 (-0.10 to 0.16) | 0.04 |
| Val | 1.15 (-0.63 to 2.93) | -0.32 (-2.10 to 1.46) | -1.11 (-2.89 to 0.67) | 0.39 (-1.39 to 2.16) | 0.62 |
| Met | 0.02 (-0.46 to 0.50) | 0.27 (-0.22 to 0.75) | -0.33 (-0.81 to 0.16) | 0.32 (-0.17 to 0.80) | 0.17 |
| Ile | 0.49 (-0.62 to 1.61) | -0.05 (-1.16 to 1.06) | -0.60 (-1.71 to 0.51) | 0.39 (-0.72 to 1.50) | 0.39 |
| Leu | 1.23 (-0.87 (3.32) | -0.32 (-2.41 to 1.78) | -1.50 (-3.60 to 0.59) | 0.26 (-1.84 to 2.35) | 0.73 |
| Tyr | 0.29 (-0.45 to 1.03) | -0.13 (-0.87 to 0.61) | -0.79 (-1.53 to -0.05)∗ | 0.00 (-0.74 to 0.74) | 0.26 |
| Phe | 0.85 (-0.38 to 2.08) | -0.37 (-1.60 to 0.86) | -1.15 (-2.38 to 0.08) | -0.04 (-1.27 to 1.19) | 0.43 |
| His | 0.49 (-0.16 to 1.14) | -0.27 (-0.92 to 0.38) | -0.49 (-1.14 to 0.16) | -0.13 (-0.78 to 0.52) | 0.23 |
| Lys | 1.56 (-0.69 to 3.81) | -0.48 (-2.73 to 1.77) | -1.52 (-3.77 to 0.72) | 0.30 (-1.95 to 2.55) | 0.79 |
| Arg | 0.90 (-2.06 to 3.86) | 0.76 (-2.20 to 3.71) | 0.6 (-2.20 to 3.72) | 1.84 (-1.12 to 4.81) | 1.04 |
Negative sign in front of the mean indicates a decrease in the concentration of the amino acid in the treated sample compared to the control.NTC- No Tumor Cells (Samples of chick embryo which were not xenografted with MDA-MB-231; negative control).
∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.