Table 4.
Concentration of amino acids in the brain. Data is shown as mean difference of treated and untreated samples in a 95% (CI) and standard error (SE); n = 9.
| Amino acid | Mean difference (g/kg) at 95% CI |
SE | |||
|---|---|---|---|---|---|
| Untreated vs. NTC | CDDP vs. Untreated | PtNPs-10 vs. Untreated | PtNPs-40 vs. Untreated | ||
| Asp | 0.94 (0.35–1.53)∗∗∗ | -0.17 (-0.76 to 0.42) | 0.31 (-0.28 to 0.90) | 0.22 (-0.37 to 0.81) | 0.21 |
| Thr | 0.35 (0.06–0.64)∗ | -0.10 (-0.05 to 0.53) | 0.04 (-0.25 to 0.33) | 0.06 (-0.23 to 0.35) | 0.10 |
| Ser | 0.54 (0.18–0.91)∗∗ | -0.30 (-0.66 to 0.07) | -0.11 (-0.48 to 0.26) | -0.10 (-0.46 to 0.27) | 0.13 |
| Glu | 1.19 (0.43–1.95)∗∗∗ | -0.32 (-1.08 to 0.44) | 0.34 (-0.42 to 1.10) | 0.28 (-0.48 to 1.04) | 0.27 |
| Pro | 0.20 (-0.64 to 1.04) | 0.00 (-0.83 to 0.84) | 1.42 (0.58–2.25)∗∗∗ | 0.79 (-0.25 to 1.63) | 0.29 |
| Gly | 0.30 (0.06–0.53)∗∗ | -0.16 (-0.40 to 0.07) | 0.05 (0.18–0.29) | 0.15 (-0.08 to 0.39) | 0.08 |
| Ala | 0.50 (0.16–0.83)∗∗ | -0.10 (-0.44 to 0.23) | 0.11 (-0.23 to 0.44) | -0.01 (-0.35 to 0.32) | 0.12 |
| Cys | 0.05 (-0.03 to 0.14) | -0.02 (-0.10 to 0.07) | 0.07 (-0.01 to 0.16) | 0.05 (-0.04 to 0.13) | 0.03 |
| Val | 0.55 (0.21–0.88)∗∗∗ | -0.21 (-0.54 to 0.13) | 0.11 (-0.23 to 0.44) | 0.15 (-0.18 to 0.49) | 0.12 |
| Met | 0.39 (0.16–0.61)∗∗∗ | -0.10 (-0.32 to 0.12) | 0.05 (-0.17 to 0.27) | -0.12 (-0.35 to 0.10) | 0.08 |
| Ile | 0.34 (-0.06 to 0.75) | -0.12 (-0.53 to 0.28) | 0.10 (-0.31 to 0.50) | -0.05 (-0.46 to 0.35) | 0.14 |
| Leu | 1.21 (0.86–1.57)∗∗∗ | -0.53 (-0.88 to -0.17)∗∗ | 0.17 (-0.19 to 0.52) | 0.33 (-0.03 to 0.68) | 0.13 |
| Tyr | 0.31 (-0.14 to 0.76) | -0.20 (-0.65 to 0.25) | 0.14 (-0.31 to 0.59) | 0.18 (-0.27 to 0.63) | 0.16 |
| Phe | 0.22 (-0.09 to 0.53) | -0.02 (-0.34 to 0.29) | 0.35 (0.04–0.66)∗ | 0.35 (0.04–0.67)∗ | 0.11 |
| His | 0.29 (0.14–0.42)∗∗∗ | -0.12 (-0.26 to 0.01) | 0.07 (-0.07 to 0.2) | 0.10 (-0.04 to 0.23) | 0.05 |
| Lys | 0.82 (0.46–1.18)∗∗∗ | -0.28 (-0.64 to 0.08) | 0.14 (-0.22 to 0.50) | 0.10 (-0.26 to 0.46) | 0.13 |
| Arg | -0.02 (-1.33 to 1.30) | 0.31 (-1.00 to 1.63) | 0.63 (-0.69 to 1.94) | 1.81 (0.49–3.12)∗∗ | 0.46 |
Negative sign in front of the mean indicates a decrease in the concentration of the amino acid in the treated sample compared to the control.NTC- No Tumor Cells (Samples of chick embryo which were not xenografted with MDA-MB-231; negative control).
∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.