Table 2.
Association of hypotension exposure with ICU mortality for different thresholds
| N | Death (%) | Adjusted OR | 95% CI | P value | |
|---|---|---|---|---|---|
| Lowest MAP ≥ 75 mmHg | 7926 | 38 (0.5%) | Reference | ||
| Lowest MAP < 75 mmHg | 69,402 | 2735 (3.9%) | 4.24 | 3.06 to 5.87 | < 0.001 |
| Lowest MAP < 65 mmHg | 51,230 | 2582 (5.0%) | 5.49 | 3.96 to 7.60 | < 0.001 |
| Lowest MAP < 55 mmHg | 17,283 | 1682 (9.7%) | 10.95 | 7.86 to 15.26 | < 0.001 |
| Lowest MAP < 45 mmHg | 1611 | 473 (29.4%) | 48.70 | 33.02 to 71.84 | < 0.001 |
| Lowest SBP ≥ 110 mmHg | 9977 | 36 (0.4%) | Reference | ||
| Lowest SBP < 110 mmHg | 67,351 | 2737 (4.1%) | 6.02 | 4.32 to 8.40 | < 0.001 |
| Lowest SBP < 100 mmHg | 55,672 | 2668 (4.8%) | 7.07 | 5.07 to 9.87 | < 0.001 |
| Lowest SBP < 90 mmHg | 33,436 | 2428 (7.3%) | 11.03 | 7.90 to 15.41 | < 0.001 |
| Lowest SBP < 80 mmHg | 9752 | 1516 (15.5%) | 25.38 | 18.06 to 35.67 | < 0.001 |
| Lowest DBP ≥ 60 mmHg | 7954 | 44 (0.6%) | Reference | ||
| Lowest DBP < 60 mmHg | 69,371 | 2729 (3.9%) | 3.82 | 2.82 to 5.17 | < 0.001 |
| Lowest DBP < 50 mmHg | 46,073 | 2407 (5.2%) | 5.29 | 3.90 to 7.19 | < 0.001 |
| Lowest DBP < 40 mmHg | 14,005 | 1295 (9.2%) | 10.78 | 7.84 to 14.82 | < 0.001 |
| Lowest DBP < 30 mmHg | 1491 | 303 (20.3%) | 31.46 | 20.78 to 47.63 | < 0.001 |
| 40 ≤ Lowest PP < 50 mmHg | 14,805 | 238 (1.6%) | Reference | ||
| Lowest PP ≥ 50 mmHg | 8419 | 80 (1%) | 0.70 | 0.53 to 0.92 | 0.011 |
| Lowest PP < 40 mmHg | 54,104 | 2455 (4.5%) | 2.37 | 2.06 to 2.73 | < 0.001 |
| Lowest PP < 30 mmHg | 26,917 | 1787 (6.6%) | 3.35 | 2.90 to 3.87 | < 0.001 |
| Lowest PP < 20 mmHg | 6278 | 687 (10.9%) | 4.99 | 4.21 to 5.90 | < 0.001 |
The entire population was categorized into subgroups using several thresholds for each blood pressure component. MAP ≥ 75 mmHg, SBP ≥ 110 mmHg, DBP ≥ 60 mmHg, and 40 ≤ PP < 50 mmHg were selected as reference groups, respectively. Multivariable logistic regression was conducted to quantitatively evaluate the risk of ICU mortality for different thresholds. Age, BMI, APACHE IVa score, ethnicity, admission type, admission year, hospital bed size, hemoglobin, albumin, WBC, BUN, and lactate were selected as covariates. The effect of hypotension exposure on ICU mortality in the lowest pressure category was smaller in PP compared to MAP, SBP, and DBP
APACHE Acute Physiology and Chronic Health Evaluation, BMI body mass index, BUN blood urea nitrogen, CI confidence interval, DBP diastolic blood pressure, ICU intensive care unit, MAP mean arterial pressure, OR odds ratio, PP pulse pressure, SBP systolic blood pressure