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. 2023 Feb 20;14:946. doi: 10.1038/s41467-023-36605-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The figure depicts the 11 annotations that were Bonferroni significant for the general factor from the bifactor model for either surface area or cortical thickness, along with the oligodendrocytes annotation that was just below the Bonferroni threshold for CT (p = 7.11E-5). Both panels depict the −log10(p) values on the multivariate enrichment estimate from Stratified Genomic SEM. p-values are one-tailed and were calculated using the ratio of the enrichment estimate over its standard error. We correct for multiple testing for Stratified Genomic SEM results by employing a strict Bonferroni correction for the number of annotations (152) and factors (6) analyzed (i.e., p < 5.48E-5). Bars significant at a Bonferroni-corrected threshold (shown as a red dashed line) are depicted with a “*”. Bars are ordered with respect to the level of significance across both CT and SA.