TABLE 3.
Comparison of the deleterious mutations between Omicron and Delta variants of SARS-CoV-2 in their different genes.
| Gene | Omicron (O, o) | Delta (Δ, δ) | Gene | Omicron (O, o) | Delta (Δ, δ) | ||||
|---|---|---|---|---|---|---|---|---|---|
| Position | Score | Position | Score | Position | Score | Position | Score | ||
| E | R61L | −1.733 | R61L | -2.8 | ORF1b | C1367T | -10.71 | H962I | -10.31 |
| N | Q306T | −3.878 | W55C | -12.869 | Y470S | -9.75 | C928W | -10.31 | |
| G164S | −2.918 | G99S | -3.861 | Y1944T | -9.397 | C942F | -10.31 | ||
| N150T | −2.645 | P162L | -3.655 | C143T | -8.549 | C939F | -10.26 | ||
| ORF1a | C3408S | −11.248 | C2989K | -11.183 | G343C | -8.378 | G670L | -9.667 | |
| W3004Y | −11.153 | W4096L | -11.111 | R1600N | -8.654 | G674I | -9.667 | ||
| G2815L | −11.044 | C4370F | -10.248 | D1815T | -8.43 | G550L | -9.667 | ||
| P4211S | −10.398 | W3481L | -10.121 | V345E | -8.289 | P618I | -9.667 | ||
| Y3364C | −10.051 | C2445S | -9.618 | L428V | -8 | Y916G | -9.663 | ||
| P2870S | −9.499 | C2851S | -9.319 | M557H | -8.8 | Y822G | -9.663 | ||
| Y2301C | −9.404 | G3795L | -9.316 | G1022T | -8.627 | D675V | -8.7 | ||
| L2298S | −9.305 | G3809L | -9.316 | T267N | -7.533 | N694F | -8.7 | ||
| P3015L | -9.21 | G3372I | -9.316 | M915S | -7.398 | Y537A | -8.7 | ||
| Y4280H | -9.11 | F2834P | -9.293 | V344E | -6.965 | Y665A | -8.7 | ||
| G3546T | −9.05 | Y4013P | -9.216 | P1645S | -6.729 | D456I | -8.4 | ||
| S2493Y | −8.185 | Y4013G | -9.183 | T453A | -6.533 | G328C | -8.3 | ||
| D2627C | −8.143 | P3642I | -9.042 | R712C | -6.366 | Y737T | -8.229 | ||
| S3264D | −7.948 | C2913H | -8.534 | C2551S | -6.206 | Y819A | -8.167 | ||
| S3195N | −7.901 | G2987L | -8.531 | L1088T | -5.751 | G2436C | -8.138 | ||
| N1576D | −7.817 | C3867I | -8.416 | V1012N | -5.751 | N619I | -8.043 | ||
| D1600C | −7.804 | C2984A | -8.387 | N2694T | -5.708 | G662L | -8.033 | ||
| G2258Y | −7.746 | Y3811A | -8.385 | H1897S | -5.583 | Y1759C | -7.875 | ||
| F3554T | −7.657 | G4244F | -8.385 | E720Y | -5.09 | P821A | -7.731 | ||
| ORF3a | W193T | −7.276 | G187C | -7.248 | E1623A | -5.026 | Q923F | -7.731 | |
| G188L | −6.6 | G172S | -4.457 | C688V | -5.003 | P528S | -7.73 | ||
| T32E | -5.505 | T221K | -4.276 | S583T | -4.971 | Y971L | -7.502 | ||
| T229T | -4.276 | N257Y | -4.257 | T984E | -4.958 | G940T | -7.502 | ||
| S162K | -3.886 | K235T | -3.276 | V2501Y | -2.89 | D295Y | -7.419 | ||
| K61L | -3.6 | S58I | -3.276 | G2510T | -2.877 | D842A | -7.396 | ||
| I62T | -3.39 | A103P | -3.229 | L342R | -2.767 | P970C | -7.278 | ||
| V256D | -2.886 | I47T | -3.067 | ORF9b | P39T | -8.478 | L52P | -7 | |
| ORF7a | E41T | -6 | Q57R | -2.629 | R47E | -5 | I45T | -5 | |
| Y97E | -5.825 | Q38K | -2.629 | L64T | -4 | V76F | -4.87 | ||
| K2Y | -5.684 | M19T | -5.571 | A29S | -3.304 | L14F | -4 | ||
| H47I | -4.667 | H3Y | -3.071 | V15T | -3 | N35S | -3.43 | ||
| R78Y | -4.333 | C58F | -7.333 | S | D1199Y | -10.528 | C301R | -9.89 | |
| T57H | -4.333 | C67F | -7.333 | N824S | -10.076 | N919W | -9.35 | ||
| V82Y | -4.667 | G42D | −7 | F318R | -9.813 | C301L | -7.9 | ||
| ORF7b | F19S | −7 | W29C | −13 | G496S | -9.424 | T478K | -7.062 | |
| ORF8 | C90T | −10.389 | I10N | −5.389 | Q498R | -9.0665 | L452R | -6.066 | |
| C25V | −10.389 | Q23H | −4.722 | Y505H | -8.709 | R158G | -5.071 | ||
| G96C | −6.611 | F120A | −4.056 | N501Y | −8.3515 | T19R | -4.075 | ||
| T80Y | −4.667 | P70L | −4.056 | Q594H | −7.994 | P681R | -3.08 | ||
| H40T | −3.556 | R115C | −3.722 | N764K | −7.6365 | D950N | -2.084 | ||
| H40S | −3.167 | G8V | −3 | N856K | −7.279 | E484A | -1.09 | ||
| G77T | −2.944 | D119V | −2.917 | L981F | −6.9215 | E484K | -0.09 | ||