TABLE 2.

Specific comparisons between healthy controls (HC) and patients with multiple sclerosis (pwMS) and each global network.

Variables	Contrasts	Estimate	Standard error	t-ratio	Adjusted P-value	Multiple R2 and adjusted R2
Density	HC-MS	0.0215	0.00612	3.518	0.0006a	0.194 (0.1732)
Efficiency	HC-MS	0.0129	0.00413	3.130	0.0021a	0.5316 (0.5164)
Clustering coefficient	HC-MS	0.0121	0.00399	3.030	0.0029a	0.5521 (0.5376)
Mean strength	HC-MS	0.91	0.288	3.164	0.0019a	0.7513 (0.7433)
Modularity	HC-MS	−0.0021	0.00169	−1.247	0.2144	0.7648 (0.7571)

For each global graph metric, comparisons between the two groups, HC and MS, were calculated. Global graph metrics differed between healthy controls MS patients. Except for modularity, these comparisons were highly significant. Adjusted p-values using holm correction are reported. HC, healthy controls; MS, multiple sclerosis; SE, standard error.

^aSignificantly different at p <0.01.