TABLE 3.
Analysis of lesion types in patients with multiple sclerosis (pwMS).
| Variables | Cognitively preserved MS (CPMS) |
Cognitively impaired MS (CIMS) |
P-value | 95% CI |
| White matter–volume | 3.17 [6.64] | 9.69 [7.13] | 0.00038 | 4.0039–9.2149 |
| White matter–number | 39 [44] | 54 [33.5] | 0.03116 | 2.0000–36.9999 |
| Juxtacortical–volume | 1.11 [2.54] | 3.42 [4.14] | 0.00106 | 1.2039–3.28199 |
| Juxtacortical–number | 31.5 [40.2] | 63 [51.2] | 0.00255 | 12.000–47.999 |
| Periventricular–volume | 0.409 [1.05] | 2.28 [2.23] | 0.00101 | 0.4820–2.1489 |
| Periventricular–number | 12 [12.5] | 19.5 [7] | 0.00752 | 1.9999–12.9999 |
| Cortical–volume | 0.0335 [0.224] | 0.272 [0.389] | 0.003844 | 0.0200–0.2719 |
| Cortical–number | 1 [5.75] | 8.5 [13.5] | 0.001847 | 1.0000–9.9999 |
| Intracortical–volume | 0 [11.5] | 17.5 [63.8] | 0.05051 | −9.354e-06–2.404e+01 |
| Intracortical–number | 0 [1] | 1 [3.75] | 0.05503 | −5.259e-05–1.999 |
| Leukocortical–volume WM | 9.5 [106] | 78 [200] | 0.00849 | 5.999–97.000 |
| Leukocortical–volume GM | 10 [73.8] | 117 [174] | 0.00357 | 11.000–119.999 |
| Leukocortical–number | 1 [4] | 7.5 [11] | 0.001873 | 1.000–8.999 |
Unit of lesion volume: mm3, values are expressed as median and interquartile range. Leukocortical–volume WM, leukocortical–volume white matter; leukocortical–volume GM, leukocortical volume gray matter. P-values and 95% CI were calculated using Mann-Whitney U-test.