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. 2023 Feb 7;11:1127949. doi: 10.3389/fbioe.2023.1127949

FIGURE 3.

FIGURE 3

BMHP-mimetic peptides, PFSSTKT and SKPPGTSS in tissue engineering. (A). BMHP1 (PFSSTKT) and BMHP2 (SKPPGTSS) recruited NSCs to local tissue, and the cell behaviors were stable, compared with Matrixgel (Gelain et al., 2006). (B). PFSSTKT in cartilage tissue engineering. RAD/PFS hydrogel did favor to the adhesion of rabbit BMSCs (A). RAD/PFS was merged in acellularized cartilage matrix scaffold to acquire functional composite scaffold, then implanted into full-depth rabbit knee cartilage defect (B). PFSSTKT was conjugated with peptide RADA-16 I to prepare functional self-assembling peptide hydrogel RAD/PFS (C). Better reconstruction of articular cartilage was found after implanting RAD/PFS/ACM composite scaffold into rabbit knee cartilage defect (D) (Lu et al., 2018). (C). SKPPGTSS in cartilage tissue engineering. Conjugation of RAD and SKPPGTSS, and fabrication of composite scaffold of RAD/SKP/DCM (A). BMSCs stayed healthy on different scaffolds (B). RAD/SKP/PFS group showed ideal neocartilage at rabbit knee cartilage defect area (C) (Sun et al., 2018).