FIGURE 5.

N-cadherin mimetic peptide HAV in cartilage engineering. (A). Crystal structure of HAVDI (Williams et al., 2000). (B). Tripeptide HAV in chondrogenesis. HAV was grafted onto MeHA hydrogel (A), and the productions of GAGs and collagen were evaluated in vitro (B) and in vivo (C) (Bian et al., 2013). (C). HAV was grafted with E-PA to get nanofiber network (A). Cells adhered the HAV/E-PA network well (B). Cells cultured on the HAV/E-PA scaffold secreted more GAGs (C), and showed higher expression of chondrogenesis (Eren Cimenci et al., 2019). (D). Self-assembling peptide KLD-HAVDI mimic the functional domain of N-cadherin (A). With stimulation of HAVDI, the secretion of GAGs and genetic expression of chondrogenesis were upgraded (B–C). Meanwhile, the subcellular localization changed (D) (Li et al., 2017a). (E). HAV was grafted to MeHA for crosslinking (A), and hydrogels of different proportion were prepared (B). HAV strengthened the expressions of early chondrogenic markers, depending on the dosage strongly (C) (Kwon et al., 2018).