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. 2023 Feb 20;13:2953. doi: 10.1038/s41598-023-28798-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CDNF increases the levels of mature BDNF in striatal neurons expressing mutant huntingtin protein. Striatal neurons expressing mutant huntingtin were treated for 24 h with 100 ng/ml CDNF or vehicle. Cell lysates were subjected to immunoblotting for BDNF, using GAPDH as loading control. Left, immunoblot. Right, histogram with quantification of the relative ratio of BDNF compared with GAPDH. Values represent mean ± SEM, *p < 0.05, unpaired t-test, n = 7.