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Diffusion of CDNF after chronic intrastriatal administration into N171-82Q mouse model (free-floating sections). Mice received an intrastriatal 4-week chronic infusion (A/P + 0.86; M/L − 1.8; D/V − 3.0) of CDNF (3 μg per 24 h). Immunohistochemical CDNF staining showed the CDNF distribution across the brain in WT animals (control, uninfused) (A), N171-82Q male mice (B), and N171-82Q female mice (C). Scale bar: 1000 μm.
