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. 2023 Feb 20;13:2953. doi: 10.1038/s41598-023-28798-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Clasping hindlimbs of N171-82Q mice. (A) Clasped hindlimbs (top photo) and unclasped hindlimbs (bottom photo). (B) Clasped hindlimbs in male mice. The CDNF-treated group presented statistically lower clasping scores than the vehicle group. *p < 0.05, **p < 0.005, Kruskal–Wallis test, Dunn post hoc. The percentage of animals with totally clasped hindlimbs in the CDNF-treated group was significantly lower than in the control group. *p < 0.05, paired t-test. (C) The clasping score in female groups did not show a difference. The number of females with totally clasped hindlimbs was significantly lower compared to the control. p = 0.05, paired t-test. Values are the means ± SEMs. N per group = 14–26.