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. 2023 Feb 20;13:2953. doi: 10.1038/s41598-023-28798-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of development of mHtt aggregates in the N171-82Q mouse model. (A) EM48-positive aggregates in N171-82Q mouse model. The black arrow points to the intranuclear inclusion. Magnification: 100×, scale bar = 10 μm. Magnification: 300×, scale bar = 5 μm. Appearance of EM48 positive aggregates in N171-82Q mice was analyzed in six points:10, 12, 14, 16, 19 and more than 19 weeks (between 20 to 30 weeks). (B) Development of huntingtin aggregates in striatum. The number of EM48 positive cells, intranuclear aggregates, and size of intranuclear inclusions increased in an age-dependent manner. (C) Formation of EM48-labelled aggregates in the neocortex. The number of intranuclear aggregates also increased in the neocortex in an age-dependent manner. (D) The number of intranuclear aggregates enhanced in the piriform cortex in an age-dependent manner. The values are expressed as means ± SEM. N = 3–5 animals per group.